Shelterin: the protein complex that shapes and safeguards human telomeres

T De Lange - Genes & development, 2005 - genesdev.cshlp.org
Added by telomerase, arrays of TTAGGG repeats specify the ends of human chromosomes.
A complex formed by six telomere-specific proteins associates with this sequence and …

Role of shelterin in cancer and aging

P Martínez, MA Blasco - Aging cell, 2010 - Wiley Online Library
Mammalian telomeres are formed by tandem repeats of the TTAGGG sequence bound by a
specialized six‐protein complex known as shelterin, which has fundamental roles in the …

Intensive meditation training, immune cell telomerase activity, and psychological mediators

TL Jacobs, ES Epel, J Lin, EH Blackburn… - …, 2011 - Elsevier
BACKGROUND: Telomerase activity is a predictor of long-term cellular viability, which
decreases with chronic psychological distress (Epel et al., 2004). Buddhist traditions claim …

A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly

MS O'Connor, A Safari, H Xin, D Liu… - Proceedings of the …, 2006 - National Acad Sciences
Mammalian telomeric proteins function through dynamic interactions with each other and
telomere DNA. We previously reported the formation of a high-molecular-mass telomeric …

TIN2 mediates functions of TRF2 at human telomeres

S Kim, C Beausejour, AR Davalos, P Kaminker… - Journal of biological …, 2004 - ASBMB
Telomeres are protective structures at chromosome ends and are crucial for genomic
stability. Mammalian TRF1 and TRF2 bind the double-stranded telomeric repeat sequence …

Influence of mindfulness-based stress reduction (MBSR) on telomerase activity in women with breast cancer (BC)

CA Lengacher, RR Reich, KE Kip… - … research for nursing, 2014 - journals.sagepub.com
Mindfulness-based stress reduction (MBSR) reduces symptoms of depression, anxiety, and
fear of recurrence among breast cancer (BC) survivors. However, the effects of MBSR (BC) …

How telomerase reaches its end: mechanism of telomerase regulation by the telomeric complex

A Bianchi, D Shore - Molecular cell, 2008 - cell.com
The telomerase enzyme, which synthesizes telomeric DNA repeats, is regulated in cis at
individual chromosome ends by the telomeric protein/DNA complex in a manner dependent …

Up-regulation of telomere-binding proteins, TRF1, TRF2, and TIN2 is related to telomere shortening during human multistep hepatocarcinogenesis

BK Oh, YJ Kim, C Park, YN Park - The American journal of pathology, 2005 - Elsevier
The telomeric repeat-binding factor 1 (TRF1), TRF2, and the TRF1-interacting nuclear
protein 2 (TIN2) are involved in telomere maintenance. We describe the regulation of …

Cancer and aging: the importance of telomeres in genome maintenance

F Rodier, SH Kim, T Nijjar, P Yaswen… - The international journal of …, 2005 - Elsevier
Telomeres are the specialized DNA–protein structures that cap the ends of linear
chromosomes, thereby protecting them from degradation and fusion by cellular DNA repair …

[HTML][HTML] Telomere biology in mammalian germ cells and during development

S Bekaert, H Derradji, S Baatout - Developmental biology, 2004 - Elsevier
The development of an organism is a strictly regulated program in which controlled gene
expression guarantees the establishment of a specific phenotype. The chromosome termini …