Proteins critical for synaptic transmission are non-uniformly distributed and assembled into
regions of high density called subsynaptic densities (SSDs) that transsynaptically align in …

Many crowded biomolecular structures in cells and tissues are inaccessible to labelling
antibodies. To understand how proteins within these structures are arranged with nanoscale …

Action potentials trigger neurotransmitter release at the presynaptic active zone with
spatiotemporal precision. This is supported by protein machinery that mediates synaptic …

Recent evidence suggests that nano-organization of proteins within synapses may control
the strength of communication between neurons in the brain. The unique subsynaptic …

Expansion microscopy (ExM) is in increasingly widespread use throughout biology because
its isotropic physical magnification enables nanoimaging on conventional microscopes. To …

A key feature of excitatory synapses is the existence of subsynaptic protein nanoclusters
(NCs) whose precise alignment across the cleft in a transsynaptic nanocolumn influences …

The subsynaptic organization of postsynaptic neurotransmitter receptors into nanoclusters
that are aligned with presynaptic release sites is essential for the high fidelity of synaptic …

Presynaptic Ca V 2 channels are essential for Ca 2+-triggered exocytosis. In addition, there
are two competing models for their roles in synapse structure. First, Ca 2+ channels or Ca 2+ …

MAGUK scaffold proteins play a central role in maintaining and modulating synaptic
signaling, providing a framework to retain and position receptors, signaling molecules, and …

Aims Synaptic strength depends strongly on the subsynaptic organisation of presynaptic
transmitter release and postsynaptic receptor densities, and their alterations are expected to …