The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

Since its debut in the biomedical research fields in 1981, zebrafish have been used as a
vertebrate model organism in more than 40,000 biomedical research studies. Especially …

While mammals have a limited capacity to repair bone defects, zebrafish can completely
regenerate amputated bony structures of their fins. Fin regeneration is dependent on …

Conditional targeted cell ablation in zebrafish would greatly expand the utility of this genetic
model system in developmental and regeneration studies, given its extensive regenerative …

We present simple and efficient methods for creating heritable modifications of the zebrafish
genome. Precisely modified alleles are generated by homologous recombination between …

Ablation studies are used to elucidate cell lineage relationships, developmental roles for
specific cells during embryogenesis and mechanisms of tissue regeneration. Previous …

The formation of the face and skull involves a complex series of developmental events
mediated by cells derived from the neural crest, endoderm, mesoderm, and ectoderm …

In recent years, the zebrafish has become one of the most prominent vertebrate model
organisms used to study the genetics underlying development, normal body function, and …

The generation of zebrafish transgenic lines that express specific fluorophores in a cell-or
tissue-specific manner is an important technique that takes full advantage of the optical …

The somites of the vertebrate embryo are clocked out sequentially from the presomitic
mesoderm (PSM) at the tail end of the embryo. Formation of each somite corresponds to one …