The calcium-sensing receptor (CaSR) is a class CG protein–coupled receptor that responds
to multiple endogenous agonists and allosteric modulators, including divalent and trivalent …

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal-dominant tumor syndrome
characterized by the occurrence of tumors in multiple endocrine tissues and nonendocrine …

Biallelic inactivation of MEN1 encoding menin in pancreatic neuroendocrine tumors
(PNETs) associated with the multiple endocrine neoplasia type 1 (MEN1) syndrome is well …

The long noncoding RNA (lncRNA) MEG3 is significantly downregulated in pancreatic
neuroendocrine tumors (PNETs). MEG3 loss corresponds with aberrant upregulation of the …

Simple Summary Neuroendocrine neoplasia comprise many distinct and rare subtypes of
cancers. Preclinical models are essential for improving understanding of these diseases …

The hyperparathyroidism-jaw tumour (HPT-JT) syndrome is an autosomal dominant disorder
characterized by occurrence of parathyroid tumours, often atypical adenomas and …

The adaptor protein 2 sigma subunit (AP2σ), encoded by AP2S1, forms a heterotetrameric
complex, with AP2α, AP2β, and AP2μ subunits, that is pivotal for clathrin mediated …

To investigate skeletal development, pathophysiological mechanisms of cartilage and bone
disease, and eventually assess innovative treatments, the mouse is a very important …

Endocrine and neuroendocrine tumors comprise a highly heterogeneous group of
neoplasms that can arise from (neuro) endocrine cells, either from endocrine glands or from …

Loss-of-function mutations of GNA11, which encodes G-protein subunit α 11 (Gα 11), a
signaling partner for the calcium-sensing receptor (CaSR), result in familial hypocalciuric …