The active form of vitamin D3, 1, 25-dihydroxyvitamin D3, is a major regulator of bone and
calcium homeostasis. In addition, this hormone also inhibits the proliferation and stimulates …

Context: There is increasing evidence that Vitamin D (Vit D) and its metabolites, besides
their well-known calcium-related functions, may also exert antiproliferative, pro …

The vitamin D endocrine system plays a central role in mineral ion homeostasis through the
actions of the vitamin D hormone, 1, 25-dihydroxyvitamin D3 [1, 25 (OH) 2D3], on the …

Simple Summary The effect of vitamin D3 on the development of breast cancer (favorable,
ineffective, or even unfavorable) depends on many factors, such as age, menopausal status …

1α, 25-Dihydroxyvitamin D3 [1, 25-(OH) 2D3] can exert its biological actions through binding
with the nuclear vitamin D receptor (VDR), a ligand-activated transcription factor. Next to …

Background Active vitamin D analogs that are less toxic than calcitriol can be useful in the
combined treatment of patients suffering from colon cancer. In the present study we …

Abstract Analogs of 1, 25-dihydroxyvitamin D 3 with a reversed configuration at C-1 or C-24
and E or Z geometry of the double bond at C-22 in the side chain or at C-5 in the triene …

Aim: The aim of this study was the evaluation of the antitumor effect of two synthetic analogs
of vitamin D, PRI-2191 and PRI-2205 in combined treatment with irinotecan or oxaliplatin on …

In our previous study, calcitriol and its analogs PRI-2191 and PRI-2205 stimulated 4T1
mouse mammary gland cancer metastasis. Therefore, we aimed to analyze the inflammatory …

Although the skin production of vitamin D is initiated by ultraviolet radiation type B (UVB), the
role vitamin D plays in antioxidative or pro-oxidative responses remains to be elucidated …