Efficient and regulated nucleocytoplasmic trafficking of macromolecules to the correct
subcellular compartment is critical for proper functions of the eukaryotic cell. The majority of …

The assembly of ribosomal subunits is a highly orchestrated process that involves a huge
cohort of accessory factors. Most eukaryotic ribosome biogenesis factors were first identified …

In the past 25 years, genetic and biochemical analyses of ribosome assembly in yeast have
identified most of the factors that participate in this complex pathway and have generated …

Blood cell formation is classically thought to occur through a hierarchical differentiation
process, although recent studies have shown that lineage commitment may occur earlier in …

The essential cellular process of ribosome biogenesis is at the nexus of various signalling
pathways that coordinate protein synthesis with cellular growth and proliferation. The fact …

Eukaryotic ribosome synthesis is a complex, energy-consuming process that takes place
across the nucleolus, nucleoplasm and cytoplasm and requires more than 200 conserved …

The proteome of cells is synthesized by ribosomes, complex ribonucleoproteins that in
eukaryotes contain 79–80 proteins and four ribosomal RNAs (rRNAs) more than 5,400 …

Mutations that target the ubiquitous process of ribosome assembly paradoxically cause
diverse tissue-specific disorders (ribosomopathies) that are often associated with an …

To achieve maximal growth, cells must manage a massive economy of ribosomal proteins (r-
proteins) and RNAs (rRNAs) to produce thousands of ribosomes every minute. Although …

We describe a novel approach to separate two ribosome populations from the same cells
and use this method in combination with RNA-seq to identify mRNAs bound to …