Surveillance studies have shown that OXA-48-like carbapenemases are the most common
carbapenemases in Enterobacterales in certain regions of the world and are being …

Joint profiling of chromatin accessibility and gene expression in individual cells provides an
opportunity to decipher enhancer-driven gene regulatory networks (GRNs). Here we present …

The liver is the largest solid organ in the body, yet it remains incompletely characterized.
Here we present a spatial proteogenomic atlas of the healthy and obese human and murine …

Although melanoma is notorious for its high degree of heterogeneity and plasticity,, the
origin and magnitude of cell-state diversity remains poorly understood. Equally, it is unclear …

Progression through fate decisions determines cellular composition and tissue architecture,
but how that same architecture may impact cell fate is less clear. We took advantage of …

In the mammalian liver, hepatocytes exhibit diverse metabolic and functional profiles based
on their location within the liver lobule. However, it is unclear whether this spatial variation …

The conclusive identity of Wnts regulating liver zonation (LZ) and regeneration (LR) remains
unclear despite an undisputed role of β-catenin. Using single-cell analysis, we identified a …

Organoids generated from human pluripotent stem cells provide experimental systems to
study development and disease, but quantitative measurements across different spatial …

Motile cilia defects impair cerebrospinal fluid (CSF) flow and can cause brain and spine
disorders. The development of ciliated cells, their impact on CSF flow, and their function in …

Abstract Knowledge of associations between fungal hosts and their bacterial associates has
steadily grown in recent years as the number and diversity of examinations have increased …