Axon degeneration is a characteristic event in many neurodegenerative conditions including
stroke, glaucoma, and motor neuropathies. However, the molecular pathways that regulate …

A wide range of insults can trigger axon degeneration, and axons respond with diverse
morphology, topology and speed. However, recent genetic, immunochemical, morphological …

The molecular triggers for axon degeneration remain unknown. We identify endogenous
Nmnat2 as a labile axon survival factor whose constant replenishment by anterograde …

NAD metabolism regulates diverse biological processes, including ageing, circadian rhythm
and axon survival. Axons depend on the activity of the central enzyme in NAD biosynthesis …

The poor response of central axons to transection underlies the bleak prognosis following
spinal cord injury. Here, we monitor individual fluorescent axons in the spinal cords of living …

Background The progressive nature of Wallerian degeneration has long been controversial.
Conflicting reports that distal stumps of injured axons degenerate anterogradely …

Axonal degeneration is an active process that has been associated with neurodegenerative
conditions triggered by mechanical, metabolic, infectious, toxic, hereditary and inflammatory …

Axon degeneration is an active, tightly controlled and versatile process of axon segment self-
destruction. Although not involving cell death, it resembles apoptosis in its logics. It involves …

Transgenic mouse lines in which a fluorescent protein is constitutively expressed under the
Thy1 gene promoter have become important models in cell biology and pathology studies of …

Degenerating myelin inhibits axon regeneration and is rapidly cleared after peripheral
(PNS) but not central nervous system (CNS) injury. To better understand mechanisms …