On the origins of SARS-CoV-2 main protease inhibitors
YL Janin - RSC Medicinal Chemistry, 2024 - pubs.rsc.org
In order to address the world-wide health challenge caused by the COVID-19 pandemic, the
3CL protease/SARS-CoV-2 main protease (SARS-CoV-2-Mpro) coded by its nsp5 gene …
3CL protease/SARS-CoV-2 main protease (SARS-CoV-2-Mpro) coded by its nsp5 gene …
[HTML][HTML] Host-targeted antivirals against SARS-CoV-2 in clinical development-prospect or disappointment?
A Schreiber, S Ludwig - Antiviral Research, 2025 - Elsevier
The global response to the COVID-19 pandemic, caused by the novel SARS-CoV-2 virus,
has seen an unprecedented surge in the development of antiviral therapies. Traditional …
has seen an unprecedented surge in the development of antiviral therapies. Traditional …
The activity and mechanism of vidofludimus as a potent enzyme inhibitor against NDM-1-positive E. coli
X Li, D Zhao, X Zhao, P Cheng, F Li, J Sun, Y Li… - European Journal of …, 2023 - Elsevier
New Delhi metallo-β-lactamase-1 (NDM-1) is the most important and prevalent enzyme
among all metallo-β-lactamases. NDM-1 can hydrolyze almost all-available β-lactam …
among all metallo-β-lactamases. NDM-1 can hydrolyze almost all-available β-lactam …
Safety and Dose-Response of Vidofludimus Calcium in Relapsing Multiple Sclerosis: Extended Results of a Placebo-Controlled Phase 2 Trial
Background and Objectives Vidofludimus calcium suppressed MRI disease activity
compared with placebo in patients with relapsing-remitting multiple sclerosis (RRMS) in the …
compared with placebo in patients with relapsing-remitting multiple sclerosis (RRMS) in the …
[HTML][HTML] Drug repurposing screen identifies vidofludimus calcium and pyrazofurin as novel chemical entities for the development of hepatitis E interventions
H Guo, D Liu, K Liu, Y Hou, C Li, Q Li, X Ding… - Virologica Sinica, 2024 - Elsevier
Hepatitis E virus (HEV) infection can cause severe complications and high mortality,
particularly in pregnant women, organ transplant recipients, individuals with pre-existing …
particularly in pregnant women, organ transplant recipients, individuals with pre-existing …
[HTML][HTML] Orally bioavailable RORγ/DHODH dual host-targeting small molecules with broad-spectrum antiviral activity
A Herrmann, C Gege, C Wangen, S Wagner, M Kögler… - Antiviral research, 2024 - Elsevier
Host-directed antivirals (HDAs) represent an attractive treatment option and a strategy for
pandemic preparedness, especially due to their potential broad-spectrum antiviral activity …
pandemic preparedness, especially due to their potential broad-spectrum antiviral activity …
Advanced virtual screening enables the discovery of a host-targeting and broad-spectrum antiviral agent
G Chilingaryan, R Izmailyan, R Grigoryan, A Shavina… - Antiviral Research, 2023 - Elsevier
We employed an advanced virtual screening (AVS) approach to identify potential inhibitors
of human dihydroorotate dehydrogenase (DHODH), a validated target for development of …
of human dihydroorotate dehydrogenase (DHODH), a validated target for development of …
Synthesis and Characterization of DHODH Inhibitors Based on the Vidofludimus Scaffold with Pronounced Anti‐SARS‐CoV‐2 Activity
C Gege, F Hahn, C Wangen, S Häge… - …, 2024 - Wiley Online Library
New strategies for the rapid development of broad‐spectrum antiviral therapies are urgently
required for emerging and re‐emerging viruses like the severe acute respiratory syndrome …
required for emerging and re‐emerging viruses like the severe acute respiratory syndrome …
[HTML][HTML] The triple combination of Remdesivir (GS-441524), Molnupiravir and Ribavirin is highly efficient in inhibiting coronavirus replication in human nasal airway …
The use of fixed dose-combinations of antivirals with different mechanisms of action has
proven a key in the successful treatment of infections with HIV and HCV. For the treatment of …
proven a key in the successful treatment of infections with HIV and HCV. For the treatment of …
Perception and Knowledge of Students of Medical Colleges towards Dietary Supplements Use for Prevention andTreatment of COVID-19
E Eltayib, N Alotaibi, M Mohamed… - Pharmacy Practice …, 2023 - dialnet.unirioja.es
Background: Dietary supplements (DSs) have grown in popularity over the last two decades,
particularly during the COVID-19 pandemic. It is critical to educate medical students, the …
particularly during the COVID-19 pandemic. It is critical to educate medical students, the …