Topical application is an important administration route for drugs requiring local action on
the skin, thereby avoiding their systemic absorption and adverse side effects. Rosmarinus …

Skin flaps are necessary in plastic and reconstructive surgery for the removal of skin cancer,
wounds, and ulcers. A skin flap is a portion of skin with its own blood supply that is partially …

Background Ivermectin (IVM) was first used as an antiparasitic agent; however, the role of
this drug evolved into a broad spectrum. Many mechanisms have been proposed, including …

Insufficient vascularization is a recurring cause of impaired pedicled skin flap healing. The
administration of adipose tissue-derived stromal cells'(ASCs') secretome is a novel …

Background: The commonly used flap models have drawbacks that limit their usefulness. In
the random skin flap model, flap necrosis is caused by both arterial and venous …

Background Some of the most complex surgical interventions to treat trauma and cancer
include the use of locoregional pedicled and free autologous tissue transfer flaps. While the …

PURPOSE: To investigate the effect of Botulinum toxin A (BoNTA) on skin flap viability in
healthy, tobacco-exposed and diabetic rats. METHODS: Ninety male Wistar rats (250-300g) …

Skin avulsion wounds are expected to be swollen and tense after trauma, and skin perfusion
can be compromised after primary closure, resulting in wound dehiscence and poor healing …

Skin flaps are employed to cover cutaneous denuded surfaces, but ensuing flap necrosis
often occurs. Previously, rats with myocardial infarction treated with lipid-core nanoparticles …

Purpose To assess the action of pentoxifylline, administered by subcutaneous route, on skin
flap tissue repair in rats, and to verify the histological aspects and biomarkers. Methods …