The human reference genome is the most widely used resource in human genetics and is
due for a major update. Its current structure is a linear composite of merged haplotypes from …

Low-cost whole-genome assembly has enabled the collection of haplotype-resolved
pangenomes for numerous organisms. In turn, this technological change is encouraging the …

INTRODUCTION Modern genomics depends on inexpensive short-read sequencing.
Sequenced reads up to a few hundred base pairs in length are computationally mapped to …

Third-generation genome sequencing technologies have led to a sharp increase in the
number of high-quality genome assemblies. This allows the comparison of multiple …

Motivation Pangenome graphs provide a complete representation of the mutual alignment of
collections of genomes. These models offer the opportunity to study the entire genomic …

A pan-genome is the nonredundant collection of genes and/or DNA sequences in a species.
Numerous studies have shown that plant pan-genomes are typically much larger than the …

Due to the development of sequencing technology and the great reduction in sequencing
costs, an increasing number of plant genomes have been assembled, and numerous …

Advances in long-read sequencing and assembly now mean that individual labs can
generate phased genomes that are more accurate and more contiguous than the original …

Since the first reported crop pangenome in 2014, advances in high‐throughput and cost‐
effective DNA sequencing technologies facilitated multiple such studies including the …

Background During the last decade, the analysis of ancient DNA (aDNA) sequence has
become a powerful tool for the study of past human populations. However, the degraded …