Exercise promotes cardioprotection in both humans and animals not only by reducing risk
factors associated with cardiovascular disease but by reducing myocardial infarction and …

Several attempts have been made, by the scientific community, to develop a unifying
hypothesis that explains the clinical syndrome of heart failure (HF). The currently widely …

Hydrogen sulfide (H2S), known as an important cellular signaling molecule, plays critical
roles in many physiological and/or pathological processes. Modulation of H2S levels could …

Under physiological conditions, cAMP signaling plays a key role in the regulation of cardiac
function. Activation of this intracellular signaling pathway mirrors cardiomyocyte adaptation …

Ample evidence identifies strong links between major depressive disorder (MDD) and both
risk of ischemic or coronary heart disease (CHD) and resultant morbidity and mortality. The …

Background: Immune cell–mediated inflammation is an essential process for mounting a
repair response after myocardial infarction (MI). The sympathetic nervous system is known to …

Selective stimulation of β 3 adrenergic-receptor (β3AR) has been shown to reduce infarct
size in a mouse model of myocardial ischemia/reperfusion. However, its functional long-term …

Background Catecholamines and β‐adrenergic receptors (β‐ARs) play an important role in
the regulation of cardiac tolerance to the impact of ischemia and reperfusion. This systematic …

Rationale: Nitric oxide (NO) bioavailability is reduced in the setting of heart failure. Nitrite
(NO2) is a critically important NO intermediate that is metabolized to NO during pathological …

Major advances in chronic heart failure (cHF) therapy have been achieved and documented
in adult patients, while research regarding the mechanisms and therapy of cHF in children …