Neuroimmune interactions in the intestine

A Wallrapp, IM Chiu - Annual Review of Immunology, 2024 - annualreviews.org
Recent advances have contributed to a mechanistic understanding of neuroimmune
interactions in the intestine and revealed an essential role of this cross talk for gut …

[HTML][HTML] The intestinal neuro-immune axis: crosstalk between neurons, immune cells, and microbes

A Jacobson, D Yang, M Vella, IM Chiu - Mucosal immunology, 2021 - Elsevier
The gastrointestinal tract is densely innervated by a complex network of neurons that
coordinate critical physiological functions. Here, we summarize recent studies investigating …

Neurotransmitters: The critical modulators regulating gut–brain axis

R Mittal, LH Debs, AP Patel, D Nguyen… - Journal of cellular …, 2017 - Wiley Online Library
Neurotransmitters, including catecholamines and serotonin, play a crucial role in
maintaining homeostasis in the human body. Studies on these neurotransmitters mainly …

Hypertension-linked pathophysiological alterations in the gut

MM Santisteban, Y Qi, J Zubcevic, S Kim… - Circulation …, 2017 - Am Heart Assoc
Rationale: Sympathetic nervous system control of inflammation plays a central role in
hypertension. The gut receives significant sympathetic innervation, is densely populated …

Bioelectric neuromodulation for gastrointestinal disorders: effectiveness and mechanisms

SC Payne, JB Furness, MJ Stebbing - Nature reviews Gastroenterology …, 2019 - nature.com
The gastrointestinal tract has extensive, surgically accessible nerve connections with the
central nervous system. This provides the opportunity to exploit rapidly advancing methods …

Psychobiotics and the gut–brain axis: in the pursuit of happiness

L Zhou, JA Foster - Neuropsychiatric disease and treatment, 2015 - Taylor & Francis
The human intestine houses an astounding number and species of microorganisms,
estimated at more than 1014 gut microbiota and composed of over a thousand species. An …

Nigral overexpression of α‐synuclein in a rat Parkinson's disease model indicates alterations in the enteric nervous system and the gut microbiome

SM O'Donovan, EK Crowley… - …, 2020 - Wiley Online Library
Background A hallmark feature of Parkinson's disease (PD) is the build‐up of α‐synuclein
protein aggregates throughout the brain; however α‐synuclein is also expressed in enteric …

[HTML][HTML] Gut microbiota are disease-modifying factors after traumatic spinal cord injury

KA Kigerl, K Mostacada, PG Popovich - Neurotherapeutics, 2018 - Elsevier
Spinal cord injury (SCI) disrupts the autonomic nervous system (ANS), impairing its ability to
coordinate organ function throughout the body. Emerging data indicate that the systemic …

Communication between the gut microbiota and peripheral nervous system in health and chronic disease

TM Cook, V Mansuy-Aubert - Gut microbes, 2022 - Taylor & Francis
Trillions of bacteria reside within our gastrointestinal tract, ideally forming a mutually
beneficial relationship between us. However, persistent changes in diet and lifestyle in the …

Bidirectional brain‐gut‐microbiota axis in increased intestinal permeability induced by central nervous system injury

X Li, X You, C Wang, X Li, Y Sheng… - CNS Neuroscience …, 2020 - Wiley Online Library
Central nervous system injuries may lead to the disorders of the hypothalamic‐pituitary‐
adrenal axis, autonomic nervous system, and enteric nervous system. These effects then …