Autophagy (self-eating) is a conserved cellular degradation process that plays important
roles in maintaining homeostasis and preventing nutritional, metabolic, and infection …

Leprosy, a disease caused by the intracellular parasite Mycobacterium leprae or
Mycobacterium lepromatosis, has affected humans for more than 4,000 years and is a …

The ubiquitination mediated by ubiquitin activating enzyme (E1), ubiquitin conjugating
enzyme (E2), and ubiquitin ligase (E3) cascade is crucial to protein degradation …

Leprosy is an infectious disease that may present different clinical forms depending on host
immune response to Mycobacterium leprae. Several studies have clarified the role of …

In recent years, advances in medical diagnosis and treatment have greatly attracted our
attention, whereas some rare diseases, such as leprosy, have not found a place in the …

P2X7 receptor is an ion channel activated by extracellular adenosine trisphosphate (eATP)
that attracted increasing attention for its role in immune reactions, neurobiology and …

Introduction The COVID-19 pandemic has highlighted the need to identify mechanisms of
antiviral host defense against SARS-CoV-2. One such mediator is interferon-g (IFN-γ) …

Mycobacterial diseases are a major public health challenge. Their causative agents include,
in order of impact, members of the Mycobacterium tuberculosis complex (causing …

Computational modeling has emerged as a critical tool in investigating the complex
molecular processes involved in biological systems and diseases. In this study, we apply …

Mycobacterial disease is an immense burden worldwide. This disease group includes
tuberculosis, leprosy (Hansen's disease), Buruli Ulcer, and non-tuberculous mycobacterial …