The membrane-associated MARCH E3 ligase family: emerging roles in immune regulation
H Lin, S Li, HB Shu - Frontiers in Immunology, 2019 - frontiersin.org
The membrane-associated RING-CH-type finger (MARCH) proteins of E3 ubiquitin ligases
have emerged as critical regulators of immune responses. MARCH proteins target immune …
have emerged as critical regulators of immune responses. MARCH proteins target immune …
The emerging roles of MARCH8 in viral infections: A double-edged Sword
The host cell membrane-associated RING-CH 8 protein (MARCH8), a member of the E3
ubiquitin ligase family, regulates intracellular turnover of many transmembrane proteins and …
ubiquitin ligase family, regulates intracellular turnover of many transmembrane proteins and …
MARCH8 inhibits Ebola virus glycoprotein, human immunodeficiency virus type 1 envelope glycoprotein, and avian influenza virus H5N1 hemagglutinin maturation
Membrane-associated RING-CH-type 8 (MARCH8) strongly blocks human
immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) incorporation into virions …
immunodeficiency virus type 1 (HIV-1) envelope glycoprotein (Env) incorporation into virions …
Overview of the membrane-associated RING-CH (MARCH) E3 ligase family
E3 ligases are critical checkpoints for protein ubiquitination, a signal that often results in
protein sorting and degradation but has also been linked to regulation of transcription and …
protein sorting and degradation but has also been linked to regulation of transcription and …
Mechanism of viral glycoprotein targeting by membrane-associated RING-CH proteins
CM Lun, AA Waheed, A Majadly, N Powell, EO Freed - MBio, 2021 - Am Soc Microbiol
An emerging class of cellular inhibitory proteins has been identified that targets viral
glycoproteins. These include the membrane-associated RING-CH (MARCH) family of E3 …
glycoproteins. These include the membrane-associated RING-CH (MARCH) family of E3 …
MARCH8 ubiquitinates the hepatitis C virus nonstructural 2 protein and mediates viral envelopment
The mechanisms that regulate envelopment of HCV and other viruses that bud intracellularly
and/or lack late-domain motifs are largely unknown. We reported that K63 polyubiquitination …
and/or lack late-domain motifs are largely unknown. We reported that K63 polyubiquitination …
Membrane-associated RING-CH 8 functions as a novel PD-L1 E3 ligase to mediate PD-L1 degradation induced by EGFR inhibitors
Expression of programmed death-ligand 1 (PD-L1) on cancer cells is a critical mechanism
contributing to immunosuppression and immune escape. PD-L1 expression may also affect …
contributing to immunosuppression and immune escape. PD-L1 expression may also affect …
[HTML][HTML] Exploration of aberrant E3 ligases implicated in Alzheimer's disease and development of chemical tools to modulate their function
FM Potjewyd, AD Axtman - Frontiers in Cellular Neuroscience, 2021 - frontiersin.org
The Ubiquitin Proteasome System (UPS) is responsible for the degradation of misfolded or
aggregated proteins via a multistep ATP-dependent proteolytic mechanism. This process …
aggregated proteins via a multistep ATP-dependent proteolytic mechanism. This process …
Zebrafish MARCH7 negatively regulates IFN antiviral response by degrading TBK1
ST Xiong, YR Ying, Z Long, JH Li, YB Zhang… - International Journal of …, 2023 - Elsevier
Membrane-associated RING-CH-type finger (MARCH) proteins have been reported to
regulate type I IFN production during host antiviral innate immunity. The present study …
regulate type I IFN production during host antiviral innate immunity. The present study …
Ring-domain e3 ligase-mediated host–virus interactions: Orchestrating immune responses by the host and antagonizing immune defense by viruses
Y Zhang, LF Li, M Munir, HJ Qiu - Frontiers in immunology, 2018 - frontiersin.org
The RING-domain E3 ligases (RING E3s), a group of E3 ligases containing one or two RING
finger domains, are involved in various cellular processes such as cell proliferation, immune …
finger domains, are involved in various cellular processes such as cell proliferation, immune …