Healthy brain functioning in mammals requires a continuous fine-tuning of gene expression.
Accumulating evidence over the last three decades demonstrates that epigenetic …

BET proteins function as histone code readers of acetylated lysins that determine the
positive regulation in transcription of genes involved in cell cycle progression, differentiation …

Animal or human models recapitulating brain ribosomopathies are incomplete, hampering
development of urgently needed therapies. Here, we generated genetic mouse and human …

Autism spectrum disorders (ASD) comprise a range of neurodevelopmental pathologies
characterized by deficits in social interaction and repetitive behaviors, collectively affecting …

Background Breast cancer is a common malignancy in women. Conventional clinical
therapies for breast cancer all display moderate clinical efficacies and limitations. It is urgent …

During recent years an increasing number of neurologic disorders due to expanded tri-, tetra-
, penta-, or hexa-nucleotide repeat motifs in introns of various genes have been described …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two
neurodegenerative disorders without cure. A GGGGCC repeat expansion in the first intron of …