The gram-positive bacterium Listeria monocytogenes is the causative agent of listeriosis, a
highly fatal opportunistic foodborne infection. Pregnant women, neonates, the elderly, and …

As the key components of innate immunity, human host defense antimicrobial peptides and
proteins (AMPs) play a critical role in warding off invading microbial pathogens. In addition …

Cell-autonomous innate immune responses against bacteria attempting to colonize the
cytosol of mammalian cells are incompletely understood. Polyubiquitylated proteins can …

For intracellular pathogens such as Salmonellae, Mycobacteriae and Brucellae, infection
requires adaptation to the intracellular environment of the phagocytic cell. The transition …

Bacterial pathogens exploit a huge range of niches within their hosts. Many pathogens can
invade non-phagocytic cells and survive within a membrane-bound compartment. However …

Covering: up to the end of 2016 Novel antimicrobial drugs are continuously needed to
counteract bacterial resistance development. An innovative molecular design strategy for …

Antimicrobial peptides (AMPs) kill microbes or inhibit their growth and are promising next-
generation antibiotics. Harnessing their full potential as antimicrobial agents will require …

Autophagy allows cells to self-digest portions of their own cytoplasm for a multitude of
physiological purposes, including innate and adaptive immunity functions. In one of its …

Salmonella enterica uses two functionally distinct type III secretion systems encoded on the
pathogenicity islands SPI‐1 and SPI‐2 to transfer effector proteins into host cells. A major …

Phagosomes are fascinating subcellular structures. After all, there are only a few
compartments that are born before our very eyes and whose development we can follow in a …