Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approaches
Y Jin, W Ji, H Yang, S Chen, W Zhang… - Signal transduction and …, 2020 - nature.com
On 12 March 2020, the outbreak of coronavirus disease 2019 (COVID-19) was declared a
pandemic by the World Health Organization. As of 4 August 2020, more than 18 million …
pandemic by the World Health Organization. As of 4 August 2020, more than 18 million …
Repurposing existing drugs for the treatment of COVID-19/SARS-CoV-2 infection: A review describing drug mechanisms of action
The outbreak of a novel coronavirus (SARS-CoV-2) has caused a major public health
concern across the globe. SARS-CoV-2 is the seventh coronavirus that is known to cause …
concern across the globe. SARS-CoV-2 is the seventh coronavirus that is known to cause …
HMGB1 and Toll-like receptors: potential therapeutic targets in autoimmune diseases
W Ren, L Zhao, Y Sun, X Wang, X Shi - Molecular Medicine, 2023 - Springer
HMGB1, a nucleoprotein, is expressed in almost all eukaryotic cells. During cell activation
and cell death, HMGB1 can function as an alarm protein (alarmin) or damage-associated …
and cell death, HMGB1 can function as an alarm protein (alarmin) or damage-associated …
Asbestos induces mesothelial cell transformation via HMGB1-driven autophagy
J Xue, S Patergnani, C Giorgi… - Proceedings of the …, 2020 - National Acad Sciences
Asbestos causes malignant transformation of primary human mesothelial cells (HM), leading
to mesothelioma. The mechanisms of asbestos carcinogenesis remain enigmatic, as …
to mesothelioma. The mechanisms of asbestos carcinogenesis remain enigmatic, as …
Glycyrrhizic acid and its hydrolyzed metabolite 18β-glycyrrhetinic acid as specific ligands for targeting nanosystems in the treatment of liver cancer
LA Stecanella, APR Bitencourt, GR Vaz, E Quarta… - Pharmaceutics, 2021 - mdpi.com
Glycyrrhizic acid and its hydrolyzed metabolite 18β-glycyrrhetinic acid, obtained from the
plant Glycyrrhiza glabra, have numerous pharmacological activities, such as anti …
plant Glycyrrhiza glabra, have numerous pharmacological activities, such as anti …
Potential neuroprotective effect of the HMGB1 inhibitor glycyrrhizin in neurological disorders
Glycyrrhizin (glycyrrhizic acid), a bioactive triterpenoid saponin constituent of Glycyrrhiza
glabra, is a traditional medicine possessing a plethora of pharmacological anti-inflammatory …
glabra, is a traditional medicine possessing a plethora of pharmacological anti-inflammatory …
Glycyrrhizic acid suppresses osteoclast differentiation and postmenopausal osteoporosis by modulating the NF-κB, ERK, and JNK signaling pathways
Postmenopausal osteoporosis, mainly caused by osteoclast-induced bone resorption, has
become a global public health burden. Natural compounds are emerging as potential …
become a global public health burden. Natural compounds are emerging as potential …
Elevated microRNA-129-5p level ameliorates neuroinflammation and blood-spinal cord barrier damage after ischemia-reperfusion by inhibiting HMGB1 and the TLR3 …
XQ Li, FS Chen, WF Tan, B Fang, ZL Zhang… - Journal of …, 2017 - Springer
Background Ischemia-reperfusion (IR) affects microRNA (miR) expression and causes
substantial inflammation. Multiple roles of the tumor suppressor miR-129-5p in cerebral IR …
substantial inflammation. Multiple roles of the tumor suppressor miR-129-5p in cerebral IR …
Keratinocyte derived HMGB1 aggravates psoriasis dermatitis via facilitating inflammatory polarization of macrophages and hyperproliferation of keratinocyte
J Chen, Y Fu, S Xiong - Molecular Immunology, 2023 - Elsevier
Psoriasis is one of the most common immune-mediated chronic inflammatory skin diseases,
involving excessive proliferation of keratinocyte and infiltration of immune cells. There are …
involving excessive proliferation of keratinocyte and infiltration of immune cells. There are …
The role of HMGB1, a nuclear damage-associated molecular pattern molecule, in the pathogenesis of lung diseases
Significance: High-mobility group protein box 1 (HMGB1), a ubiquitous nuclear protein,
regulates chromatin structure and modulates the expression of many genes involved in the …
regulates chromatin structure and modulates the expression of many genes involved in the …