Clearance of apoptotic cells by tissue epithelia: a putative role for hepatocytes in liver efferocytosis

SP Davies, GM Reynolds, Z Stamataki - Frontiers in immunology, 2018 - frontiersin.org
Toxic substances and microbial or food-derived antigens continuously challenge the liver,
which is tasked with their safe neutralization. This vital organ is also important for the …

Colonic coffee phenols metabolites, dihydrocaffeic, dihydroferulic, and hydroxyhippuric acids protect hepatic cells from TNF-α-induced inflammation and oxidative …

A Sánchez-Medina, M Redondo-Puente… - International Journal of …, 2023 - mdpi.com
Coffee presents beneficial health properties, including antiobesity effects. However, its
effects on inflammation are controversial. Hydroxycinnamic acids are the main coffee …

Bile acid induction of cytokine expression by macrophages correlates with repression of hepatic cholesterol 7α-hydroxylase

JH Miyake, SL Wang, RA Davis - Journal of Biological Chemistry, 2000 - ASBMB
In the studies reported herein, we show that two complementary experimental models:
inbred strains of mice (ie C57BL/6 and C3H/HeJ), and a differentiated line of rat hepatoma …

Tumor necrosis factor α-dependent up-regulation of Lrh-1 and Mrp3 (Abcc3) reduces liver injury in obstructive cholestasis

A Bohan, WS Chen, LA Denson, MA Held… - Journal of Biological …, 2003 - ASBMB
Mrp3 (Abcc3) is markedly induced following bile duct ligation (BDL) in the rat and in some
human cholestatic liver diseases and is believed to ameliorate liver injury in this setting …

Induction of tolerogenic dendritic cells by activated TGF-β/Akt/Smad2 signaling in RIG-I-deficient stemness-high human liver cancer cells

M Zhong, C Zhong, W Cui, G Wang, G Zheng, L Li… - BMC cancer, 2019 - Springer
Abstract Background Dendritic cells (DCs) alter their role from being immunostimulatory to
immunosuppressive at advanced stages of tumor progression, but the influence of cancer …

Biology and significance of T‐cell apoptosis in the liver

S Park, D Murray, B John… - Immunology and cell …, 2002 - Wiley Online Library
The liver has emerged as an organ with distinct immunological properties. In this review, we
summarize evidence that shows that the liver can remove apoptotic, or non‐apoptotic but …

Feline infectious peritonitis as a systemic inflammatory disease: Contribution of liver and heart to the pathogenesis

AJ Malbon, S Fonfara, ML Meli, S Hahn, H Egberink… - Viruses, 2019 - mdpi.com
Feline infectious peritonitis (FIP) is a fatal immune-mediated disease of cats, induced by
feline coronavirus (FCoV). A combination of as yet poorly understood host and viral factors …

Targeting androgen receptor (AR)→ IL12A signal enhances efficacy of sorafenib plus NK cells immunotherapy to better suppress HCC progression

L Shi, H Lin, G Li, RA Jin, J Xu, Y Sun, WL Ma… - Molecular cancer …, 2016 - AACR
Gender disparity has long been considered as a key to fully understand hepatocellular
carcinoma (HCC) development. At the same time, immunotherapy related to IL12 still need …

Cytokines alter the expression and activity of the multidrug resistance transporters in human hepatoma cell lines; analysis using RT‐PCR and cDNA microarrays

G Lee, M Piquette‐Miller - Journal of pharmaceutical sciences, 2003 - Elsevier
Pro‐inflammatory cytokines suppress the hepatic expression of the multidrug resistance
transporters in rodents, indicating potential usefulness in chemotherapy. Our objective was …

[HTML][HTML] Hepatitis B virus activates signal transducer and activator of transcription 3 supporting hepatocyte survival and virus replication

M Hösel, M Quasdorff, M Ringelhan, H Kashkar… - Cellular and molecular …, 2017 - Elsevier
Background & Aims The human hepatitis B virus (HBV) is a major cause of chronic hepatitis
and hepatocellular carcinoma, but molecular mechanisms driving liver disease and …