Simple Summary Spine metastases are a common life-threatening complication of
advanced-stage malignancies and often result in poor prognosis. Symptomatic spine …

Skeletal-related events (SREs) are complications of bone metastases and carry a significant
patient and economic burden. Denosumab is a receptor activator of nuclear factor-κB ligand …

Background and objective Innovations have improved outcomes in advanced prostate
cancer (PC). Nonetheless, we continue to lack high-level evidence on a variety of topics that …

Modification of the extracellular matrix (ECM) is a critical aspect of developing a metastasis-
supportive organ niche. Recent work investigating ECM changes that facilitate metastasis …

PURPOSE There is strong interest from patients, researchers, the pharmaceutical industry,
medical journal editors, funders of research, and regulators in sharing clinical trial data for …

The skeleton is the most common site of secondary disease in breast cancer and prostate
cancer, with up to 80% of patients with advanced disease developing bone metastases …

Background Innovations in treatments, imaging and molecular characterisation have
improved outcomes for people with advanced prostate cancer; however, many aspects of …

Abstract Treatment for breast cancer, including endocrine therapies, can contribute to bone
loss and increase the risk of osteoporosis and fractures. Management of bone health in …

Abstract The Breast Committee of the Arbeitsgemeinschaft Gynäkologische Onkologie
(German Gynecological Oncology Group, AGO) presents the 2022 update of the evidence …

Simple Summary Major progress has been achieved in stage-IV bone metastatic patients to
control over the disease progression, thereby resulting in longer survival. Self-autonomy and …