Unnatural helical peptidic foldamers as protein segment mimics
P Sang, J Cai - Chemical Society Reviews, 2023 - pubs.rsc.org
Unnatural helical peptidic foldamers have attracted considerable attention owing to their
unique folding behaviours, diverse artificial protein binding mechanisms, and promising …
unique folding behaviours, diverse artificial protein binding mechanisms, and promising …
PTH/PTHrP receptor signaling, allostery, and structures
I Sutkeviciute, LJ Clark, AD White, TJ Gardella… - Trends in Endocrinology …, 2019 - cell.com
The parathyroid hormone (PTH) type 1 receptor (PTHR) is the canonical G protein-coupled
receptor (GPCR) for PTH and PTH-related protein (PTHrP) and the key regulator of calcium …
receptor (GPCR) for PTH and PTH-related protein (PTHrP) and the key regulator of calcium …
[HTML][HTML] Advancing oral delivery of biologics: Machine learning predicts peptide stability in the gastrointestinal tract
The oral delivery of peptide therapeutics could facilitate precision treatment of numerous
gastrointestinal (GI) and systemic diseases with simple administration for patients. However …
gastrointestinal (GI) and systemic diseases with simple administration for patients. However …
Improved GPCR ligands from nanobody tethering
Antibodies conjugated to bioactive compounds allow targeted delivery of therapeutics to cell
types of choice based on that antibody's specificity. Here we develop a new type of …
types of choice based on that antibody's specificity. Here we develop a new type of …
Hormone Analogues with Unique Signaling Profiles from Replacement of α-Residue Triads with β/γ Diads
R Gibadullin, TW Kim, LML Tran… - Journal of the American …, 2023 - ACS Publications
We have applied an underexplored backbone modification strategy to generate new
analogues of peptides that activate two clinically important class B1 G protein-coupled …
analogues of peptides that activate two clinically important class B1 G protein-coupled …
Use of backbone modification to enlarge the spatiotemporal diversity of parathyroid hormone receptor-1 signaling via biased agonism
S Liu, FG Jean-Alphonse, AD White… - Journal of the …, 2019 - ACS Publications
The type-1 parathyroid hormone receptor (PTHR1), which regulates calcium homeostasis
and tissue development, has two native agonists, parathyroid hormone (PTH) and PTH …
and tissue development, has two native agonists, parathyroid hormone (PTH) and PTH …
Receptor selectivity from minimal backbone modification of a polypeptide agonist
S Liu, RW Cheloha, T Watanabe… - Proceedings of the …, 2018 - National Acad Sciences
Human parathyroid hormone (PTH) and N-terminal fragments thereof activate two receptors,
hPTHR1 and hPTHR2, which share∼ 51% sequence similarity. A peptide comprising the …
hPTHR1 and hPTHR2, which share∼ 51% sequence similarity. A peptide comprising the …
Altered signaling at the PTH receptor via modified agonist contacts with the extracellular domain provides a path to prolonged agonism in vivo
The parathyroid hormone type 1 receptor (PTHR1), a Class B GPCR, is activated by long
polypeptides, including drugs for osteoporosis and hypoparathyroidism. The PTHR1 …
polypeptides, including drugs for osteoporosis and hypoparathyroidism. The PTHR1 …
Ureidopeptide GLP-1 analogues with prolonged activity in vivo via signal bias and altered receptor trafficking
J Fremaux, C Venin, L Mauran, R Zimmer… - Chemical …, 2019 - pubs.rsc.org
The high demand of the pharmaceutical industry for new modalities to address the
diversification of biological targets with large surfaces of interaction led us to investigate the …
diversification of biological targets with large surfaces of interaction led us to investigate the …
Backbone Modification Provides a Long-Acting Inverse Agonist of Pathogenic, Constitutively Active PTH1R Variants
Parathyroid hormone 1 receptor (PTH1R) plays a key role in mediating calcium homeostasis
and bone development, and aberrant PTH1R activity underlies several human diseases …
and bone development, and aberrant PTH1R activity underlies several human diseases …