The aminoacyl-tRNA synthetases are an essential and universally distributed family of
enzymes that plays a critical role in protein synthesis, pairing tRNAs with their cognate …

Ever since the “great oxidation event,” Earth's cellular life forms had to cope with the danger
of reactive oxygen species (ROS) affecting the integrity of biomolecules and hampering …

Translation regulation largely occurs during initiation, which features ribosome assembly
onto mRNAs and selection of the translation start site. Short, upstream ORFs (uORFs) …

Faithful translation of mRNA into the corresponding polypeptide is a complex multistep
process, requiring accurate amino acid selection, transfer RNA (tRNA) charging and mRNA …

Amino acids are present in a variety of matrices from biological fluids to plant and animal
tissues. We discuss options for amino acid extraction, sample clean-up and protein …

Aminoacyl‐tRNA synthetases (AARSs) charge tRNA with their cognate amino acids. Many
other enzymes use amino acids as substrates, yet discrimination against noncognate amino …

By linking amino acids to their codon assignments, transfer RNAs (tRNAs) are essential for
protein synthesis and translation fidelity. Some human tRNA variants cause amino acid mis …

Although regulation of translation fidelity is an essential process 1–7, diverse organisms and
organelles have differing requirements of translational accuracy 8–15, and errors in gene …

The damage to cellular components by reactive oxygen species, termed oxidative stress,
both increases with age and likely contributes to age-related diseases including Alzheimer's …

Aminoacyl-tRNA synthetases (aaRSs) are essential enzymes that provide the ribosome with
aminoacyl-tRNA substrates for protein synthesis. Mutations in aaRSs lead to various …