As one of the most successful therapeutic target families, G protein-coupled receptors
(GPCRs) have experienced a transformation from random ligand screening to knowledge …

G protein-coupled receptors (GPCRs) are the largest class of cell surface receptors in the
genome and the most successful family of targets of FDA-approved drugs. New frontiers in …

Agonists of seven-transmembrane receptors, also known as G protein-coupled receptors
(GPCRs), do not uniformly activate all cellular signalling pathways linked to a given seven …

Allosteric ligands bind to G protein-coupled receptors (GPCRs; also known as seven-
transmembrane receptors) at sites that are distinct from the sites to which endogenous …

G protein coupled receptors (GPCRs) convey signals across membranes via interaction with
G proteins. Originally, an individual GPCR was thought to signal through one G protein …

It is now widely accepted that G protein-coupled receptors (GPCRs) are highly dynamic
proteins that adopt multiple active states linked to distinct functional outcomes. Furthermore …

In addition to G protein-coupled receptor (GPCR) desensitization and endocytosis, β-arrestin
recruitment to ligand-stimulated GPCRs promotes non-canonical signalling cascades …

Chronic inflammation is a component of numerous diseases including autoimmune,
metabolic, neurodegenerative, and cancer. The discovery and characterization of …

Short lipidated peptide sequences derived from various intracellular loop regions of G
protein-coupled receptors (GPCRs) are named pepducins and act as allosteric modulators …

The angiotensin type 1 receptor (AT1R) and its octapeptide ligand, angiotensin II (AngII),
engage multiple downstream signaling pathways, including those mediated by …