Cochlear health and cochlear-implant function

KC Schvartz-Leyzac, DJ Colesa, DL Swiderski… - Journal of the …, 2023 - Springer
The cochlear implant (CI) is widely considered to be one of the most innovative and
successful neuroprosthetic treatments developed to date. Although outcomes vary, CIs are …

Neurotrophin gene therapy to promote survival of spiral ganglion neurons after deafness

PA Leake, O Akil, H Lang - Hearing research, 2020 - Elsevier
Hearing impairment is a major health and economic concern worldwide. Currently, the
cochlear implant (CI) is the standard of care for remediation of severe to profound hearing …

Evaluating psychophysical polarity sensitivity as an indirect estimate of neural status in cochlear implant listeners

KN Jahn, JG Arenberg - Journal of the Association for Research in …, 2019 - Springer
The physiological integrity of spiral ganglion neurons is presumed to influence cochlear
implant (CI) outcomes, but it is difficult to measure neural health in CI listeners. Modeling …

Changes in the electrically evoked compound action potential over time after implantation and subsequent deafening in guinea pigs

D Ramekers, H Benav, SFL Klis, H Versnel - Journal of the Association for …, 2022 - Springer
The electrically evoked compound action potential (eCAP) is a direct measure of the
responsiveness of the auditory nerve to electrical stimulation from a cochlear implant (CI) …

Polarity sensitivity in pediatric and adult cochlear implant listeners

KN Jahn, JG Arenberg - Trends in Hearing, 2019 - journals.sagepub.com
Modeling data suggest that sensitivity to the polarity of an electrical stimulus may reflect the
integrity of the peripheral processes of the spiral ganglion neurons. Specifically, better …

How electrically evoked compound action potentials in chronically implanted guinea pigs relate to auditory nerve health and electrode impedance

KC Schvartz-Leyzac, DJ Colesa… - The Journal of the …, 2020 - pubs.aip.org
This study examined how multiple measures based on the electrically evoked compound
action potential (ECAP) amplitude-growth functions (AGFs) were related to estimates of …

Changes over time in the electrically evoked compound action potential (ECAP) interphase gap (IPG) effect following cochlear implantation in Guinea pigs

KC Schvartz-Leyzac, DJ Colesa, CJ Buswinka… - Hearing research, 2019 - Elsevier
The electrically-evoked compound action potential (ECAP) is correlated with spiral ganglion
neuron (SGN) density in cochlear implanted animals. In a previous study, we showed that …

[HTML][HTML] Reexamining the effects of electrode location on measures of neural health in cochlear implant users

KC Schvartz-Leyzac, BE Pfingst - JASA Express Letters, 2023 - pubs.aip.org
The electrically evoked compound action potentials (ECAPs) amplitude-growth function
(AGF) slope correlates with spiral ganglion neuron (SGN) density in the cochlear implanted …

The effect of aging on the electrically evoked compound action potential

BS Mussoi, CJ Brown - Otology & Neurotology, 2020 - journals.lww.com
Objectives: To examine the effect of aging on electrically evoked compound action potential
(eCAP) growth functions and their relationship with speech recognition in noise in cochlear …

Using the electrically-evoked compound action potential (ECAP) interphase gap effect to select electrode stimulation sites in cochlear implant users

KC Schvartz-Leyzac, TA Zwolan, BE Pfingst - Hearing research, 2021 - Elsevier
Studies in cochlear implanted animals show that the IPG Effect for ECAP growth functions
(ie, the magnitude of the change in ECAP amplitude growth function (AGF) slope or peak …