Cellular hypoxia occurs when the demand for sufficient molecular oxygen needed to
produce the levels of ATP required to perform physiological functions exceeds the vascular …

Having a hypoxic microenvironment is a common and salient feature of most solid tumors.
Hypoxia has a profound effect on the biological behavior and malignant phenotype of …

Molecular oxygen (O2) is essential for most biological reactions in mammalian cells. When
the intracellular oxygen content decreases, it is called hypoxia. The process of hypoxia is …

Chronic (continuous, non-interrupted) hypoxia and cycling (intermittent, transient) hypoxia
are two types of hypoxia occurring in malignant tumors. They are both associated with the …

The transferrin receptor 1 (TfR1), also known as cluster of differentiation 71 (CD71), is a type
II transmembrane glycoprotein that binds transferrin (Tf) and performs a critical role in …

Hypoxia and inflammation have been associated with a number of pathological conditions,
in particular inflammatory diseases. While hypoxia is mainly associated with the activation of …

The disability, mortality and costs due to ionizing radiation (IR)-induced osteoporotic bone
fractures are substantial and no effective therapy exists. Ionizing radiation increases cellular …

Hypoxia is a hallmark of inflamed, infected or damaged tissue, and the adaptation to
inadequate tissue oxygenation is regulated by hypoxia-inducible factors (HIFs). HIFs are key …

Both tumor hypoxia and dysregulated metabolism are classical features of cancer. Recent
analyses have revealed complex interconnections between oncogenic activation, hypoxia …

Cancer, the main cause of human deaths in the modern world is a group of diseases.
Anticancer drug discovery is a challenge for scientists because of involvement of multiple …