Dysregulated miRNA in progression of hepatocellular carcinoma: A systematic review

Y Mizuguchi, T Takizawa, H Yoshida… - Hepatology …, 2016 - Wiley Online Library
Hepatocellular carcinoma (HCC) is the fifth most frequent cancer and the third cause of
cancer‐related mortality worldwide. The primary risk factor for HCC is liver cirrhosis …

The key role of microRNAs in initiation and progression of hepatocellular carcinoma

S Khan, DY Zhang, JY Zhang, MK Hayat, J Ren… - Frontiers in …, 2022 - frontiersin.org
Hepatocellular carcinoma (HCC) is the main type of primary liver malignancy and the fourth
leading cause of cancer-related death worldwide. MicroRNAs (miRNAs), a type of non …

Exosome‐transferred long non‐coding RNA ASMTL‐AS1 contributes to malignant phenotypes in residual hepatocellular carcinoma after insufficient radiofrequency …

D Ma, X Gao, Z Liu, X Lu, H Ju, N Zhang - Cell Proliferation, 2020 - Wiley Online Library
Abstract Objectives Long non‐coding RNAs (lncRNAs) are emerging RNA regulators in
cancer progression, including in hepatocellular carcinoma (HCC). Recently, insufficient …

Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response

SZ Li, QP Shu, Y Song, HH Zhang, Y Liu, BX Jin… - Nature …, 2019 - nature.com
MAVS is essential for antiviral immunity, but the molecular mechanisms responsible for its
tight regulation remain poorly understood. Here, we show that NLK inhibits the antiviral …

[HTML][HTML] Role of microRNAs in hepatocellular carcinoma

Z Zhu, X Zhang, G Wang, H Zheng - Hepatitis monthly, 2014 - ncbi.nlm.nih.gov
Results: Researchers have reported that miRNAs can repress the expression of important
cancer-related genes and might be helpful in the diagnosis and treatment of cancer. During …

Role of cyclin‐dependent kinases (CDKs) in hepatocellular carcinoma: Therapeutic potential of targeting the CDK signaling pathway

S Shen, DC Dean, Z Yu, Z Duan - Hepatology Research, 2019 - Wiley Online Library
Liver cancer is the fourth leading cause of cancer related mortality in the world, with
hepatocellular carcinoma (HCC) representing the most common primary subtype. Two …

[HTML][HTML] A kinome screen reveals that Nemo-like kinase is a key suppressor of hepatic gluconeogenesis

YX Ji, Y Wang, PL Li, L Cai, XM Wang, L Bai, Z Liu… - Cell Metabolism, 2021 - cell.com
Antihyperglycemic therapy is an important priority for the treatment of type 2 diabetes (T2D).
Excessive hepatic glucose production (HGP) is a major cause of fasting hyperglycemia …

Nemo-like kinase, a multifaceted cell signaling regulator

T Ishitani, S Ishitani - Cellular signalling, 2013 - Elsevier
Nemo-like kinase (NLK) is an evolutionarily conserved MAP kinase-related kinase. Although
NLK was originally identified as a Drosophila gene affecting cell movement during eye …

MiR-101 functions as a tumor suppressor by directly targeting nemo-like kinase in liver cancer

Q Shen, HJ Bae, JW Eun, HS Kim, SJ Park, WC Shin… - Cancer letters, 2014 - Elsevier
Abstract Nemo-like kinase (NLK), an evolutionarily conserved MAP kinase-related kinase,
has been reported to be involved in the development of hepatocellular carcinoma (HCC) …

M-HIFU inhibits tumor growth, suppresses STAT3 activity and enhances tumor specific immunity in a transplant tumor model of prostate cancer

X Huang, F Yuan, M Liang, HW Lo, ML Shinohara… - PloS one, 2012 - journals.plos.org
Objective In this study, we explored the use of mechanical high intensity focused ultrasound
(M-HIFU) as a neo-adjuvant therapy prior to surgical resection of the primary tumor. We also …