The enantioselective synthesis of spirocycles has long been pursued by organic chemists.
Despite their unique 3D properties and presence in several natural products, the difficulty in …

Chiral spirooxindoles are privileged heterocyclic motifs, which are widely found in natural
alkaloids and pharmaceuticals. Moreover, the construction of chiral spiro-cyclic frameworks …

Introduction: Spirooxindole, a unique and versatile scaffold, has been widely studied in
some fields such as pharmaceutical chemistry and synthetic chemistry. Especially in the …

A new bifunctional squaramide organocatalyst derived from l-proline mediated the first
enantioselective synthesis of dihydrospiro [indoline-3, 4′-pyrano [2, 3-c] pyrazole] …

Spirocyclic compounds fascinate the synthetic chemists due to their privileged ring system
and efficacy in drug discovery. Many natural compounds comprise spirocyclic moiety in their …

Asymmetric synthesis plays an important role in the synthesis of therapeutics and natural
products. Asymmetric oxindoles with a stereogenic quaternary carbon center are extensively …

Isatin has been used in design and synthesis of diverse types of heterocyclic and
carbocyclic compounds and considered as a valuable building block in organic synthesis …

Spirocyclic compounds, particularly spirooxindoles that comprise a tetrahedral sp3‐
hybridized carbon atom at the C‐3 position of an orthogonally shaped bicyclic structure have …

Carbonyl transformations involving enolates and/or enamines have been used for various
types of bond‐forming reactions. In this account, catalysts and catalyst systems that have …

Although the asymmetric hydroalkoxylation of 1, 3-dienes has been achieved recently, the
development of a modular and mechanistically distinct strategy for concurrently introducing …