Transfer RNAs (tRNAs) have been historically viewed as non-dynamic adaptors that decode
the genetic code into proteins. Recent work has uncovered dynamic regulatory roles for …

Arginase activity and arginine metabolism in immune cells have important consequences for
health and disease. Their dysregulation is commonly observed in cancer, autoimmune …

Many types of human cancers suppress the expression of argininosuccinate synthase 1
(ASS1), a rate-limiting enzyme for arginine production. Although dependency on exogenous …

Cancers commonly reprogram translation and metabolism, but little is known about how
these two features coordinate in cancer stem cells. Here we show that glioblastoma stem …

Aminoacyl-tRNA synthetases can promote or suppress cancer progression by regulating
codon-dependent translation. A study now shows that valine aminoacyl-tRNA synthetase …

Codon optimality refers to the effect that codon composition has on messenger RNA (mRNA)
stability and translation level and implies that synonymous codons are not silent from a …

Maintenance methylation, of palindromic CpG dinucleotides at DNA replication forks, is
crucial for the faithful mitotic inheritance of genomic 5-methylcytosine (5mC) methylation …

Cysteine substitutants emerge in lung cancer proteomes during arginine restriction -
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Chemical exchange saturation transfer (CEST) MRI has been identified as a novel
alternative to classical diagnostic imaging. Over the last several decades, many studies …

Cancer is a complex disease that is caused by multiple genetic factors. Researchers have
been studying protein domain mutations to understand how they affect the progression and …