Autophagy is a process that targets various intracellular elements for degradation.
Autophagy can be non-selective—associated with the indiscriminate engulfment of cytosolic …

Sumoylation is an essential post-translational modification that is catalysed by a small
number of modifying enzymes but regulates thousands of target proteins in a dynamic …

As a central hub for cellular metabolism and intracellular signaling, the mitochondrion is a
pivotal organelle, dysfunction of which has been linked to several human diseases including …

The evolution of AMPK and its homologs enabled exquisite responsivity and control of
cellular energetic homeostasis. Recent work has been critical in establishing the …

Mitochondrial dysfunction has been associated with neurodegeneration in Parkinson's
disease (PD) for over 30 years. Despite this, the role of mitochondrial dysfunction as an …

Mitophagy mediated by the recessive Parkinson's disease genes PINK1 and Parkin
responds to mitochondrial damage to preserve mitochondrial function. In the pathway …

Cullin-RING ubiquitin ligases (CRLs) are dynamic modular platforms that regulate myriad
biological processes through target-specific ubiquitylation. Our knowledge of this system …

Ubiquitylation is a critical post-translational modification that controls a wide variety of
processes in eukaryotes. Ubiquitin chains of different topologies are specialized for different …

Cellular homeostasis requires the swift and specific removal of damaged material. Selective
autophagy represents a major pathway for the degradation of such cargo material. This is …

Selective autophagy specifically eliminates damaged or superfluous organelles, maintaining
cellular health. In this process, a double membrane structure termed an autophagosome …