The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

Maintenance of systemic homeostasis and the response to nutritional and environmental
challenges require the coordination of multiple organs and tissues. To respond to various …

Lysophosphatidic acid (LPA) is a small ubiquitous lipid found in vertebrate and
nonvertebrate organisms that mediates diverse biological actions and demonstrates …

Adipocytes account for the largest proportion among the cells that comprise breast tissue;
therefore, they are considered to be a critical cell type in the tumor microenvironment of …

Lysophosphatidic acid (LPA) is a small, ubiquitous phospholipid that acts as an extracellular
signaling molecule by binding to and activating at least five known G protein–coupled …

Lysophospholipids encompass a diverse range of small, membrane‐derived phospholipids
that act as extracellular signals. The signalling properties are mediated by 7 …

When caloric intake exceeds caloric expenditure, the positive caloric balance and storage of
energy in adipose tissue often causes adipocyte hypertrophy and visceral adipose tissue …

BACKGROUND & AIMS: Pruritus is a common and disabling symptom in cholestatic
disorders. However, its causes remain unknown. We hypothesized that potential pruritogens …

Autotaxin (ATX), or nucleotide pyrophosphatase-phosphodiesterase 2, is a secreted
lysophospholipase D that promotes cell migration, metastasis, and angiogenesis. ATX …

Lysophosphatidic acid (LPA, 1-or 2-acyl-sn-glycerol 3-phosphate) is a simple phospholipid
but displays an intriguing cell biology that is mediated via interactions with G protein …