During neurodegenerative disease, the multifunctional RNA-binding protein TDP-43
undergoes a vast array of post-translational modifications, including phosphorylation …

Transactive response DNA binding protein (TDP-43) is a key player in neurodegenerative
diseases. In this review, we have gathered and presented structural information on the …

Pathological aggregation of the transactive response DNA-binding protein of 43 kDa (TDP-
43) is associated with several neurodegenerative disorders, including ALS, frontotemporal …

Despite the prominent role of TDP-43 in neurodegeneration, its physiological and
pathological functions are not fully understood. Here, we report an unexpected role of TDP …

526-residue Fused in sarcoma (FUS) undergoes liquid–liquid phase separation (LLPS) for
its functions, which can further transit into pathological aggregation. ATP and nucleic acids …

FUS and TDP-43, two RNA-binding proteins from the heterogeneous nuclear
ribonucleoprotein family, have gained significant attention in the field of neurodegenerative …

Proteins function in the crowded cellular environments with high salt concentrations, thus
facing tremendous challenges of misfolding/aggregation which represents a pathological …

ATP is the universal energy currency but mysteriously its cellular concentration is much
higher than that needed for providing energy. Recently ATP was decoded to act as a …

Adenosine triphosphate (ATP) provides energy for cellular processes but has recently been
found to act also as a hydrotrope to maintain protein homeostasis. ATP bivalently binds the …

RNA dysregulation likely contributes to disease pathogenesis of amyotrophic lateral
sclerosis (ALS) and other neurodegenerative diseases. A pathological form of the …