Excess microtubule and F-actin formation mediates shortening and loss of primary cilia in response to a hyperosmotic milieu

H Otani, R Nakazato, K Koike, K Ohta… - Journal of Cell …, 2024 - journals.biologists.com
The primary cilium is a small organelle protruding from the cell surface that receives signals
from the extracellular milieu. Although dozens of studies have reported that several genetic …

Diverse microtubule-binding repeats regulate TPX2 activities at distinct locations within the spindle

Z Liang, J Huang, Y Wang, S Hua, K Jiang - Journal of Cell Biology, 2025 - rupress.org
TPX2 is an elongated molecule containing multiple α-helical repeats. It stabilizes
microtubules (MTs), promotes MT nucleation, and is essential for spindle assembly …

KIF2A maintains cytokinesis in mouse embryonic stem cells by stabilising intercellular bridge microtubules

L Stockmann, H Kabbech, GJ Kremers, B van Herk… - bioRxiv, 2024 - biorxiv.org
Cytokinesis, the final stage of cell division, serves to physically separate daughter cells while
ensuring correct segregation of cellular components. In cultured naive mouse embryonic …

Microtubule dynamic instability is sensitive to specific biological viscogens in vitro

A Molines, C Edrington, SC Tetlalmatzi, F Chang… - bioRxiv, 2024 - biorxiv.org
Cytoplasm is a viscous, crowded, and heterogeneous environment, and its local viscosity
and degree of macromolecular crowding have significant effects on cellular reaction rates …

Systematic Identification of Microtubule Inner Proteins Reveals JPT2 as a Key Regulator of Lumen Microenvironment and Drug Sensitivity

J Shao, R Zhang, P Wu, H Xu, Z Zhou, L Gu, L Wang… - bioRxiv, 2025 - biorxiv.org
Microtubules are primarily studied for the interactions of proteins that bind to their outer
surfaces and ends, while the regulatory mechanisms within the microtubule lumen …

[HTML][HTML] Quantitative Comparison of Monomeric StayGold Variants Using Protein Nanocages in Living Cells

G Viola, KA Jacobs, J Lemière, ML Kutys… - bioRxiv, 2024 - pmc.ncbi.nlm.nih.gov
To standardize comparison of fluorescent proteins and independently determine which
monomeric StayGold variant is best for live microscopy, we analyzed fluorescent protein …

[HTML][HTML] Microtubule-associated protein, MAP1B, encodes functionally distinct polypeptides

TC Tan, Y Shen, LB Stine, B Mitchell, K Okada… - Journal of Biological …, 2024 - Elsevier
Microtubule-associated protein, MAP1B, is crucial for neuronal morphogenesis and
disruptions in MAP1B function are correlated with neurodevelopmental disorders. MAP1B …