High-dose intravenous vitamin C, a promising multi-targeting agent in the treatment of cancer

F Böttger, A Vallés-Martí, L Cahn… - Journal of experimental & …, 2021 - Springer
Mounting evidence indicates that vitamin C has the potential to be a potent anti-cancer
agent when administered intravenously and in high doses (high-dose IVC). Early phase …

Intravenous vitamin C for reduction of cytokines storm in acute respiratory distress syndrome

A Boretti, BK Banik - PharmaNutrition, 2020 - Elsevier
The recent outbreak of Covid19 has required urgent treatments for numerous patients. No
suitable vaccines or antivirals are available for Covid19. The efficiency against Covid19 of …

High-dose vitamin C enhances cancer immunotherapy

A Magrì, G Germano, A Lorenzato, S Lamba… - Science translational …, 2020 - science.org
Vitamin C (VitC) is known to directly impair cancer cell growth in preclinical models, but
there is little clinical evidence on its antitumoral efficacy. In addition, whether and how VitC …

Vitamin C as prophylaxis and adjunctive medical treatment for COVID-19?

AF Feyaerts, W Luyten - Nutrition, 2020 - Elsevier
Severe acute respiratory syndrome coronavirus 2 causes the potentially fatal coronavirus
disease 2019 (COVID-19). Already during the outbreak of the severe acute respiratory …

Pro‐and antioxidant effects of vitamin C in cancer in correspondence to its dietary and pharmacological concentrations

E Pawlowska, J Szczepanska… - Oxidative Medicine and …, 2019 - Wiley Online Library
Vitamin C is an antioxidant that may scavenge reactive oxygen species preventing DNA
damage and other effects important in cancer transformation. Dietary vitamin C from natural …

Multiple effects of ascorbic acid against chronic diseases: Updated evidence from preclinical and clinical studies

M Berretta, V Quagliariello, N Maurea, R Di Francia… - Antioxidants, 2020 - mdpi.com
Severe disease commonly manifests as a systemic inflammatory process. Inflammation is
associated withthe enhanced production of reactive oxygen and nitrogen species and with a …

A randomized, open-label, multicenter, phase 3 study of high-dose vitamin C plus FOLFOX±bevacizumab versus FOLFOX±bevacizumab in unresectable untreated …

F Wang, MM He, J Xiao, YQ Zhang, XL Yuan… - Clinical Cancer …, 2022 - AACR
Purpose: To compare the efficacy and safety of high-dose vitamin C plus FOLFOX±
bevacizumab versus FOLFOX±bevacizumab as first-line treatment in patients with metastatic …

Understanding the therapeutic potential of ascorbic acid in the battle to overcome cancer

J Reang, PC Sharma, VK Thakur, J Majeed - Biomolecules, 2021 - mdpi.com
Cancer, a fatal disease, is also one of the main causes of death worldwide. Despite various
developments to prevent and treat cancer, the side effects of anticancer drugs remain a …

[HTML][HTML] Strategies to tackle RAS-mutated metastatic colorectal cancer

G Patelli, F Tosi, A Amatu, G Mauri, A Curaba… - ESMO open, 2021 - Elsevier
The RAS oncogene is among the most commonly mutated in cancer. RAS mutations are
identified in about half of patients diagnosed with metastatic colorectal cancer (mCRC) …

[HTML][HTML] Therapeutic use of vitamin C in cancer: physiological considerations

FJ Roa, E Peña, M Gatica, K Escobar-Acuña… - Frontiers in …, 2020 - frontiersin.org
Since the early studies of William J. McCormick in the 1950s, vitamin C has been proposed
as a candidate for the treatment of cancer. A number of reports have shown that …