Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …

Directed neuronal differentiation of human pluripotent stem cells (hPSCs), neural
progenitors, or fibroblasts using transcription factors has allowed for the rapid and highly …

Accurate modeling of human neuronal cell biology has been a long‐standing challenge.
However, methods to differentiate human induced pluripotent stem cells (iPSCs) to neurons …

Neurodegenerative diseases are characterized by progressive cell loss leading to disruption
of the structure and function of the central nervous system. Amyotrophic lateral sclerosis …

For the promise of human induced pluripotent stem cells (iPSCs) to be realized, it is
necessary to ask if and how efficiently they may be differentiated to functional cells of various …

Induced pluripotent stem cells (iPSCs) outwardly appear to be indistinguishable from
embryonic stem cells (ESCs). A study of gene expression profiles of mouse and human …

Stem cell–based approaches have received much hype as potential treatments for
neurodegenerative disorders. Indeed, transplantation of stem cells or their derivatives in …

BACKGROUND Decades of laboratory and clinical investigation have led to successful
therapies using hematopoietic stem cells (HSCs), but few other cell therapies have …

Stem cell therapies have shown promise in promoting recovery in stroke but have been
limited by poor cell survival and differentiation. We have developed a hyaluronic acid (HA) …

Human induced pluripotent stem (iPS) cells are similar to embryonic stem (ES) cells, and
can proliferate intensively and differentiate into a variety of cell types. However, the hepatic …