[HTML][HTML] The physiological, biochemical, and molecular roles of zinc transporters in zinc homeostasis and metabolism

T Kambe, T Tsuji, A Hashimoto… - Physiological …, 2015 - journals.physiology.org
Zinc is involved in a variety of biological processes, as a structural, catalytic, and intracellular
and intercellular signaling component. Thus zinc homeostasis is tightly controlled at the …

Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets

B Chen, P Yu, WN Chan, F Xie, Y Zhang… - … and Targeted Therapy, 2024 - nature.com
Zinc metabolism at the cellular level is critical for many biological processes in the body. A
key observation is the disruption of cellular homeostasis, often coinciding with disease …

Role of zinc homeostasis in the pathogenesis of diabetes and obesity

A Fukunaka, Y Fujitani - International journal of molecular sciences, 2018 - mdpi.com
Zinc deficiency is a risk factor for obesity and diabetes. However, until recently, the
underlying molecular mechanisms remained unclear. The breakthrough discovery that the …

The SLC30 family of zinc transporters–a review of current understanding of their biological and pathophysiological roles

L Huang, S Tepaamorndech - Molecular aspects of medicine, 2013 - Elsevier
Two families of zinc (Zn2+) transporters are involved in zinc homeostasis in the body, SLC30
(ZnT, zinc transporter) and SLC39 (ZIP, Zinc (Zn2+)–Iron (Fe2+) Permease). The two zinc …

Antidiabetic activity of zinc oxide and silver nanoparticles on streptozotocin-induced diabetic rats

A Alkaladi, AM Abdelazim, M Afifi - International journal of molecular …, 2014 - mdpi.com
The use of nanoparticles in medicine is an attractive proposition. In the present study, zinc
oxide and silver nanoparticles were evaluated for their antidiabetic activity. Fifty male albino …

[HTML][HTML] Activating transcription factor 6 mediates inflammatory signals in intestinal epithelial cells upon endoplasmic reticulum stress

ST Stengel, A Fazio, S Lipinski, MT Jahn, K Aden, G Ito… - Gastroenterology, 2020 - Elsevier
Background & Aims Excess and unresolved endoplasmic reticulum (ER) stress in intestinal
epithelial cells (IECs) promotes intestinal inflammation. Activating transcription factor 6 …

Zinc and insulin in pancreatic beta-cells

YV Li - Endocrine, 2014 - Springer
Abstract Zinc (Zn 2+) is an essential element crucial for growth and development, and also
plays a role in cell signaling for cellular processes like cell division and apoptosis. In the …

Solute carrier transporters as potential targets for the treatment of metabolic disease

T Schumann, J König, C Henke, DM Willmes… - Pharmacological …, 2020 - Elsevier
The solute carrier (SLC) superfamily comprises more than 400 transport proteins mediating
the influx and efflux of substances such as ions, nucleotides, and sugars across biological …

Zinc oxide nanoparticles show antidiabetic activity in streptozotocin-induced Type 1 and 2 diabetic rats

RD Umrani, KM Paknikar - Nanomedicine, 2014 - Taylor & Francis
Aim: The correlation of diabetes and an imbalance in zinc homeostasis makes zinc-based
therapy an attractive proposition. In this study, zinc oxide nanoparticles were evaluated for …

Micronutrients in autoimmune diseases: possible therapeutic benefits of zinc and vitamin D

I Wessels, L Rink - The Journal of nutritional biochemistry, 2020 - Elsevier
A functional immune system is essential for healthy life. This is achieved by the coordinate
activation and interaction of different immune cells. One should be aware that activation of …