Asymmetric cell division (ACD) is an evolutionarily conserved mechanism used by
prokaryotes and eukaryotes alike to control cell fate and generate cell diversity. A detailed …

Single-cell multiomics technologies typically measure multiple types of molecule from the
same individual cell, enabling more profound biological insight than can be inferred by …

To clarify the role of microglia in brain homeostasis and disease, an understanding of their
maintenance, proliferation and turnover is essential. The lifespan of brain microglia …

Protein misfolding is a major driver of ageing‐associated frailty and disease pathology.
Although all cells possess multiple, well‐characterised protein quality control systems to …

Maintaining a healthy proteome throughout life is critical for proper somatic stem cell
function, but the complexities of the stem cell response to increases in damaged or …

Cells of unicellular and multicellular eukaryotes can respond to certain environmental cues
by arresting the cell cycle and entering a reversible state of quiescence. Quiescent cells do …

The astonishing progress in the field of stem cell biology during the past 40 years has
transformed both science and medicine. Neural stem cells (NSCs) are the stem cells of the …

Longevity reflects the ability to maintain homeostatic conditions necessary for life as an
organism ages. A long-lived organism must contend not only with environmental hazards …

Oocytes are among the longest-lived cells in the body and need to preserve their cytoplasm
to support proper embryonic development. Protein aggregation is a major threat for …

Medical advances made over the last century have increased our lifespan, but age-related
diseases are a fundamental health burden worldwide. Aging is therefore a major risk factor …