Enhancing cancer immunotherapy via inhibition of soluble epoxide hydrolase
AG Kelly, W Wang, E Rothenberger… - Proceedings of the …, 2024 - National Acad Sciences
Cancer therapy, including immunotherapy, is inherently limited by chronic inflammation-
induced tumorigenesis and toxicity within the tumor microenvironment. Thus, stimulating the …
induced tumorigenesis and toxicity within the tumor microenvironment. Thus, stimulating the …
AKR1C3 in carcinomas: from multifaceted roles to therapeutic strategies
M Li, L Zhang, J Yu, X Wang, L Cheng, Z Ma… - Frontiers in …, 2024 - frontiersin.org
Aldo-Keto Reductase Family 1 Member C3 (AKR1C3), also known as type 5 17β-
hydroxysteroid dehydrogenase (17β-HSD5) or prostaglandin F (PGF) synthase, functions as …
hydroxysteroid dehydrogenase (17β-HSD5) or prostaglandin F (PGF) synthase, functions as …
Proteostasis perturbation of N-Myc leveraging HSP70 mediated protein turnover improves treatment of neuroendocrine prostate cancer
N-Myc is a key driver of neuroblastoma and neuroendocrine prostate cancer (NEPC). One
potential way to circumvent the challenge of undruggable N-Myc is to target the protein …
potential way to circumvent the challenge of undruggable N-Myc is to target the protein …
Prognostic role of Androgen Receptor splice variant 7 (AR-V7) in the pathogenesis of breast cancer
Abstract Background The Androgen Receptor (AR) has emerged as an endocrine therapy
target in Breast Cancer, exhibiting up to 80% expression in clinical cases. AR-V7, a …
target in Breast Cancer, exhibiting up to 80% expression in clinical cases. AR-V7, a …
Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer
Abstract Treatment-induced neuroendocrine prostate cancer (t-NEPC) often arises from
adenocarcinoma via lineage plasticity in response to androgen receptor signaling inhibitors …
adenocarcinoma via lineage plasticity in response to androgen receptor signaling inhibitors …
Multi-omics strategy reveals that Cordyceps sinensis ameliorates sepsis-associated acute kidney injury via reprogramming of mitochondrial energy metabolism and …
L Chen, T Yang, J Wu, G Cheng, M Zhao… - Acta Materia …, 2024 - scienceopen.com
Cordyceps sinensis (CS) has been widely used as a dietary supplement or traditional
medicine for the prevention, treatment, and prognostication of various diseases, because of …
medicine for the prevention, treatment, and prognostication of various diseases, because of …
DHODH inhibition represents a therapeutic strategy and improves abiraterone treatment in castration-resistant prostate cancer
S Guo, M Miao, Y Wu, D Pan, Q Wu, Z Kang, J Zeng… - Oncogene, 2024 - nature.com
Castration-resistant prostate cancer (CRPC) is an aggressive disease with poor prognosis,
and there is an urgent need for more effective therapeutic targets to address this challenge …
and there is an urgent need for more effective therapeutic targets to address this challenge …
Patient-Derived Conditionally Reprogrammed Cells in Prostate Cancer Research
Prostate cancer (PCa) remains a leading cause of mortality among American men, with
metastatic and recurrent disease posing significant therapeutic challenges due to a limited …
metastatic and recurrent disease posing significant therapeutic challenges due to a limited …
Design and Evaluation of NSAID Derivatives as AKR1C3 Inhibitors for Breast Cancer Treatment through Computer-Aided Drug Design and In Vitro Analysis
V Fonseca-Benítez, P Acosta-Guzmán, JE Sánchez… - Molecules, 2024 - mdpi.com
Breast cancer is a major global health issue, causing high incidence and mortality rates as
well as psychological stress for patients. Chemotherapy resistance is a common challenge …
well as psychological stress for patients. Chemotherapy resistance is a common challenge …