Insight in schizophrenia spectrum disorders: relationship with behavior, mood and perceived quality of life, underlying causes and emerging treatments

PH Lysaker, ML Pattison, BL Leonhardt… - World …, 2018 - Wiley Online Library
Poor insight in schizophrenia is prevalent across cultures and phases of illness. In this
review, we examine the recent research on the relationship of insight with behavior, mood …

Meta-analysis of structural and functional brain abnormalities in schizophrenia with persistent negative symptoms using activation likelihood estimation

T Zhu, Z Wang, C Zhou, X Fang, C Huang, C Xie… - Frontiers in …, 2022 - frontiersin.org
Background Persistent negative symptoms (PNS) include both primary and secondary
negative symptoms that persist after adequate treatment, and represent an unmet …

Insight and psychosis: the next 30 years

AS David - The British Journal of Psychiatry, 2020 - cambridge.org
Academic interest in the concept of insight in psychosis has increased markedly over the
past 30 years, prompting this selective appraisal of the current state of the art. Considerable …

Connectome-based patterns of first-episode medication-naive patients with schizophrenia

LB Cui, Y Wei, YB Xi, A Griffa, SC De Lange… - Schizophrenia …, 2019 - academic.oup.com
Emerging evidence indicates that a disruption in brain network organization may play an
important role in the pathophysiology of schizophrenia. The neuroimaging fingerprint …

Childhood trauma associated white matter abnormalities in first-episode schizophrenia

L Asmal, S Kilian, S Du Plessis, F Scheffler… - Schizophrenia …, 2019 - academic.oup.com
Schizophrenia is associated with brain connection irregularities within and between brain
regions. Childhood trauma increases the risk of schizophrenia suggesting that the …

Cognitive deficits and white matter abnormalities in never-treated first-episode schizophrenia

M Yang, S Gao, X Zhang - Translational Psychiatry, 2020 - nature.com
Cognitive impairment is viewed as a core symptom of schizophrenia (SCZ), but its
pathophysiological mechanism remains unclear. White matter (WM) disruption is considered …

Bilateral anterior corona radiata microstructure organisation relates to impaired social cognition in schizophrenia

T Burke, L Holleran, D Mothersill, J Lyons… - Schizophrenia …, 2023 - Elsevier
Abstract Objective The Corona Radiata (CR) is a large white matter tract in the brain
comprising of the anterior CR (aCR), superior CR (sCR), and posterior CR (pCR), which …

Changes in insight over the first 24 months of treatment in schizophrenia spectrum disorders

L Phahladira, L Asmal, S Kilian, B Chiliza… - Schizophrenia …, 2019 - Elsevier
Background While insight in schizophrenia improves with treatment, significant impairments
often persist. The degree of persistence is not well characterised. Aims We assessed patient …

Structure/function interrelationships and illness insight in patients with schizophrenia: a multimodal MRI data fusion study

ML Otte, MM Schmitgen, ND Wolf, KM Kubera… - European Archives of …, 2023 - Springer
Illness insight in schizophrenia (SZ) has an important impact on treatment outcome,
integration into society and can vary over the course of the disorder. To deal with and treat …

Strontium ion attenuates lipopolysaccharide‐stimulated proinflammatory cytokine expression and lipopolysaccharide‐inhibited early osteogenic differentiation of …

L Wei, Y Jiang, W Zhou, S Liu, Y Liu… - Journal of …, 2018 - Wiley Online Library
Background and objective Periodontitis is a chronic inflammatory disease characterized by
the destruction of the periodontium. The strontium ion (Sr2+) can prevent the bone loss …