During fertilization, the egg and the sperm are supposed to contribute precisely one copy of
each chromosome to the embryo. However, human eggs frequently contain an incorrect …

The oocyte is recognised as the largest cell in mammalian species and other multicellular
organisms. Mitochondria represent a high proportion of the cytoplasm in oocytes and …

Organismal aging exhibits wide-ranging hallmarks in divergent cell types across tissues,
organs, and systems. The advancement of single-cell technologies and generation of rich …

STUDY QUESTION Are human ovarian aging and the age-related female fertility decline
caused by oxidative stress and mitochondrial dysfunction in oocytes? SUMMARY ANSWER …

The ovary is the first organ to age in the human body, affecting both fertility and overall
health. However, the biological mechanisms underlying human ovarian aging remain poorly …

Abnormal resumption of meiosis and decreased oocyte quality are hallmarks of maternal
aging. Transcriptional silencing makes translational control an urgent task during meiosis …

Meiosis, a key process in the creation of haploid gametes, is a complex cellular division
incorporating unique timing and intricate chromosome dynamics. Abnormalities in this …

Decreased oocyte quality and compromised embryo development are particularly prevalent
in older females, but the aging-related cellular processes and effective ameliorative …

Simple Summary Artificial reproduction techniques (ART) are used widely in human
medicine to overcome infertility, with about one in seven couples being concerned in the …

Background Millions of children have been born throughout the world thanks to ARTs, the
harmlessness of which has not yet been fully demonstrated. For years, efforts to evaluate the …