Molecular photoswitches enable dynamic control of processes with high spatiotemporal
precision, using light as external stimulus, and hence are ideal tools for different research …

Many lead compounds fail to reach clinical trials despite being potent because of low
bioavailability attributed to their insufficient solubility making solubility a primary and crucial …

The urea functionality is inherent to numerous bioactive compounds, including a variety of
clinically approved therapies. Urea containing compounds are increasingly used in …

There is a continued desire in biomedical research to reduce the number and duration of
design cycles required to optimize lead compounds into high-quality chemical probes or …

Screening of small-molecule libraries is a productive method for identifying both chemical
probes of disease-related targets and potential starting points for drug discovery. In this …

Diabetes is a leading cause of morbidity and mortality worldwide, and predicted to affect
over 500 million people by 2030. However, this growing burden of disease has not been met …

Medium-sized heterocycles (with 8 to 11 atoms) constitute important structural components
of several biologically active natural compounds and represent promising scaffolds in …

Cannabinoid 1 receptor (CB1R) allosteric ligands hold a far-reaching therapeutic promise.
We report the application of fluoro-and nitrogen-walk approaches to enhance the drug-like …

The unique hydrogen binding capabilities of ureas make them an important functional group
to make drug-target interactions and thus incorporated in small molecules displaying broad …

Conformational Restriction and Steric Hindrance in Medicinal Chemistry - ScienceDirect
Skip to main contentSkip to article Elsevier logo Journals & Books Search RegisterSign in …