Ten Years of BrainAGE as a Neuroimaging Biomarker of Brain Aging: What Insights Have We Gained?

K Franke, C Gaser - Frontiers in neurology, 2019 - frontiersin.org
With the aging population, prevalence of neurodegenerative diseases is increasing, thus
placing a growing burden on individuals and the whole society. However, individual rates of …

Predicting age using neuroimaging: innovative brain ageing biomarkers

JH Cole, K Franke - Trends in neurosciences, 2017 - cell.com
The brain changes as we age and these changes are associated with functional
deterioration and neurodegenerative disease. It is vital that we better understand individual …

[HTML][HTML] Multimodality neuroimaging brain-age in UK biobank: relationship to biomedical, lifestyle, and cognitive factors

JH Cole - Neurobiology of aging, 2020 - Elsevier
The brain-age paradigm is proving increasingly useful for exploring aging-related disease
and can predict important future health outcomes. Most brain-age research uses structural …

Predicting brain age with deep learning from raw imaging data results in a reliable and heritable biomarker

JH Cole, RPK Poudel, D Tsagkrasoulis, MWA Caan… - NeuroImage, 2017 - Elsevier
Abstract Machine learning analysis of neuroimaging data can accurately predict
chronological age in healthy people. Deviations from healthy brain ageing have been …

Training confounder-free deep learning models for medical applications

Q Zhao, E Adeli, KM Pohl - Nature communications, 2020 - nature.com
The presence of confounding effects (or biases) is one of the most critical challenges in
using deep learning to advance discovery in medical imaging studies. Confounders affect …

ENIGMA and global neuroscience: A decade of large-scale studies of the brain in health and disease across more than 40 countries

PM Thompson, N Jahanshad, CRK Ching… - Translational …, 2020 - nature.com
This review summarizes the last decade of work by the ENIGMA (E nhancing N euro I
maging G enetics through M eta A nalysis) Consortium, a global alliance of over 1400 …

Anatomically interpretable deep learning of brain age captures domain-specific cognitive impairment

C Yin, P Imms, M Cheng, A Amgalan… - Proceedings of the …, 2023 - National Acad Sciences
The gap between chronological age (CA) and biological brain age, as estimated from
magnetic resonance images (MRIs), reflects how individual patterns of neuroanatomic aging …

Brain age and other bodily 'ages': implications for neuropsychiatry

JH Cole, RE Marioni, SE Harris, IJ Deary - Molecular psychiatry, 2019 - nature.com
As our brains age, we tend to experience cognitive decline and are at greater risk of
neurodegenerative disease and dementia. Symptoms of chronic neuropsychiatric diseases …

Burnout, career satisfaction, and well-being among US neurologists in 2016

NA Busis, TD Shanafelt, CM Keran, KH Levin… - Neurology, 2017 - AAN Enterprises
Objective: To study prevalence of and factors that contribute to burnout, career satisfaction,
and well-being in US neurologists. Methods: A total of 4,127 US American Academy of …

Brain-age prediction: A systematic comparison of machine learning workflows

S More, G Antonopoulos, F Hoffstaedter, J Caspers… - NeuroImage, 2023 - Elsevier
The difference between age predicted using anatomical brain scans and chronological age,
ie, the brain-age delta, provides a proxy for atypical aging. Various data representations and …