Breast cancer is one of the world's leading causes of oncological disease-related death. It is
characterized by a high degree of heterogeneity on the clinical, morphological, and …

Background The p53 and HSF1 transcription factors are key players in cellular responses to
stress. They activate important signaling pathways triggering adaptive mechanisms that …

Metastatic breast cancer is the most common cancer in women after skin cancer, with a 5-
year survival rate of 26%. Due to its high prevalence, it is important to develop therapies that …

HER2 is overexpressed in 20% of invasive breast cancers (BCs) and correlates with a more
aggressive disease. Until the advent of targeted agents, HER2 was associated with worse …

Despite success of ERBB2-targeted therapies such as lapatinib, resistance remains a major
clinical concern. Multiple compensatory receptor tyrosine kinase (RTK) pathways are known …

Background. Pharmacotherapy with medicinal plants is a promising approach to treat
cancer. Cinnamon is a medicinal plant whose properties have been proven in various fields …

Simple Summary Most solid tumors share mutations in TP53 that is thus considered one of
the main cancer driver genes. Mutations in TP53 occur very early during tumor development …

AIM To confirm the changes in proteins related with hypoxia-induced retinal cell death and
to assess the effects of resveratrol (Res). METHODS The therapeutic effect of Res was …

Lapatinib, a small molecule ErbB2/EGFR inhibitor, is FDA-approved for the treatment of
metastatic ErbB2-overexpressing breast cancer; however, lapatinib resistance is an …

Background As key negative regulators of gene expression, microRNAs (miRNAs) play an
important role in the onset and progression of hepatocellular carcinoma (HCC). This study …