Platelets—blood cells continuously produced from megakaryocytes mainly in the bone
marrow—are implicated not only in haemostasis and arterial thrombosis, but also in other …

The immunoglobulin receptor GPVI (glycoprotein VI) is selectively expressed on
megakaryocytes and platelets and is currently recognized as a receptor for not only collagen …

Super-enhancers (SEs) are cell-specific DNA cis-regulatory elements that can supervise the
transcriptional regulation processes of downstream genes. SEdb 2.0 (http://www. licpathway …

A targeted high-throughput sequencing (HTS) panel test for clinical diagnostics requires
careful consideration of the inclusion of appropriate diagnostic-grade genes, the ability to …

Blood cells contain functionally important intracellular structures, such as granules, critical to
immunity and thrombosis. Quantitative variation in these structures has not been subjected …

Novel platelet and megakaryocyte transcriptome analysis allows prediction of the full or
theoretical proteome of a representative human platelet. Here, we integrated the established …

The three-dimensional organization of the genome is linked to its function. For example,
regulatory elements such as transcriptional enhancers control the spatio-temporal …

Plasma levels of the multimeric glycoprotein von Willebrand factor (VWF) constitute a
complex quantitative trait with a continuous distribution and wide range in the normal …

Capture Hi-C is widely used to obtain high-resolution profiles of chromosomal interactions
involving, at least on one end, regions of interest such as gene promoters. Signal detection …

Platelets are cellular elements that are physiologically involved in hemostasis, inflammation,
thrombotic events, and various human diseases. There is a link between the activation of …