The Na+-K+-ATPase, or sodium pump, is the membrane-bound enzyme that maintains the
Na+ and K+ gradients across the plasma membrane of animal cells. Because of its …

The purpose of this review is to provide an account of the physiological substrates of cAMP-
dependent protein kinase (PKA). Discussion is limited to just over 100 unique gene products …

One of the most interesting groups of substances of marine origin, from structural and
pharmacological points of view are polyether toxins, which generally pre-sent a great …

Most neurons co-express two catalytic isoforms of Na, K-ATPase, the ubiquitous α1, and the
more selectively expressed α3. Although neurological syndromes are associated with α3 …

During the past decade, it has become evident that dopamine plays an important role in the
regulation of renal function and blood pressure. Dopamine exerts its actions via a class of …

Control over the Na, K-ATPase function plays a central role in adaptation of the organisms to
hypoxic and anoxic conditions. As the enzyme itself does not possess O2 binding sites its …

It now generally is agreed that Na, K-ATPase, in addition to its role in the maintenance of
Na+ and K+ gradients across the cell membrane, plays a role in communicating information …

Mounting evidence suggests that the ion pump, Na, K-ATPase, can, in the presence of
ouabain, act as a signal transducer. A prominent binding motif linking the Na, K-ATPase to …

Phosphorylation is a widely used, reversible means of regulating enzymatic activity. Among
the important phosphorylation targets are the Na+, K+-and H+, K+-ATPases that pump ions …

Objective: The mechanism by which the cardiac Na/K ATPase (NKA) is regulated by
phosphorylation is controversial. We have used the perforated-patch technique to limit cell …