Immune cells can protect against tumor progression by killing cancer cells, while aberrant
expression of the immune checkpoint protein PD‐L1 (programmed death ligand 1) in cancer …

Abstract ING genes (ING1–5) were identified has tumor suppressor genes. ING proteins are
characterized as Type II TSGs since they are involved in the control of cell proliferation …

Gene expression is regulated by a number of interrelated posttranslational modifications of
histones, including citrullination. For example, peptidylarginine deminase 4 (PAD4) converts …

Purpose The inhibitor of growth (ING) family consists of ING1, ING2, ING3, ING4 and ING5,
which function as the type II tumor suppressors. INGs regulate cell proliferation, senescence …

Successful glioma gene therapy lays on two important factors, the therapeutic genes and
efficient delivery vehicles to cross the blood–brain barrier (BBB) and reach gliomas. In this …

Increasing evidence shows that dysregulation of microRNAs (miRNAs) is involved in
malignant transformation. We investigated the clinical significance of miR-650 and its …

Background/Aims: The aim of this study was to investigate the role of microRNA miR-761 in
the progression and metastasis of non-small cell lung cancer (NSCLC), and the …

As a tumor suppressor protein, the inhibitor of growth 4 (ING4) has an important role in many
cellular processes including cell cycle progression, proliferation, apoptosis, DNA damage …

Background In the last decade, studies in hepatocellular carcinoma (HCC) demonstrate
dysregulation of miRNAs expression. For instance, miR‐650 has been implicated in gastric …

Growing evidence has suggested that inhibitor of growth 4 (ING4), a novel member of ING
family proteins, plays a critical role in the development and progression of different tumors …