NY-ESO-1 or New York esophageal squamous cell carcinoma 1 is a well-known cancer-
testis antigen (CTAs) with re-expression in numerous cancer types. Its ability to elicit …

The mechanisms that maintain the stability of chromosome ends have broad impact on
genome integrity in all eukaryotes. Budding yeast is a premier organism for telomere …

Galloway–Mowat syndrome (GAMOS) is an autosomal-recessive disease characterized by
the combination of early-onset nephrotic syndrome (SRNS) and microcephaly with brain …

The development of cancer vaccines has been intensively pursued over the past 50 years
with modest success. However, recent advancements in the fields of genetics, molecular …

Multiple myeloma (MM) is a plasma cell malignancy and the second most common
hematological neoplasm in adults, comprising 1.8% of all cancers. With an annual incidence …

Covalent nucleotide modifications in noncoding RNAs affect a plethora of biological
processes, and new functions continue to be discovered even for well-known modifying …

Monothiol glutaredoxins with the CGFS sequence at the active site are widespread among
prokaryotes and eukaryotes. Two subclasses exist, those with a single glutaredoxin domain …

The highly conserved Kinase, Endopeptidase and Other Proteins of small Size (KEOPS)/
Endopeptidase‐like and Kinase associated to transcribed Chromatin (EKC) protein complex …

N6-threonyl-carbamoylation of adenosine 37 of ANN-type tRNAs (t6A) is a universal
modification essential for translational accuracy and efficiency. The t6A pathway uses two …

Abstract KEOPS (K inase, E ndopeptidase and O ther P roteins of S mall size) is a five-
subunit protein complex that is highly conserved in eukaryotes and archaea and is essential …