Dysfunction of lysosomes, the primary hydrolytic organelles in animal cells, is frequently
associated with aging and age‐related diseases. At the cellular level, lysosomal dysfunction …

Lysosomal acid lipase (LAL) deficiency is hyperinflammatory disease caused by the
deficiency of the enzyme which hydrolyzes cholesterol esters and triglycerides; thus, there is …

Wolman disease is a lethal rare autosomal recessive disorder defined by the deficiency of
acid lipase enzyme. The disease is a lysosomal storage disease. Multiple organs such as …

Lysosomal enzymes are implicated in autophagy and senescence. Hepatic lysosomal
enzymes have not been studied in Primary Biliary Cholangitis (PBC). We therefore …

Lysosomal acid lipase deficiency is a rare heterogeneous autosomal recessive
heterogeneous genetic disorder whose manifestations often result in severe morbidity and …

Antecedentes: las malformaciones congénitas (MC) son un desafío para la salud pública
por su elevada prevalencia y consecuencias a lo largo de la vida. Se han identificado …