Dendritic cells (DCs) are highly specialized antigen presenting cells of the immune system
which play a key role in regulating immune responses. Depending on the method of antigen …

Despite the progress of conventional vaccines, improvements are clearly required due to
concerns about the weak immunogenicity of these vaccines, intrinsic instability in vivo …

A major challenge in vaccine formulations is the stimulation of both the humoral and cellular
immune response for well-defined antigens with high efficacy and safety. Adjuvant research …

In the quest to treat intracellular infectious diseases and virus infection, nanoparticles (NPs)
have been considered to be efficient tools for inducing potent immune responses …

Abstract Poly (lactide-co-glycolide)(PLGA) particles have strong potential as antigen delivery
systems. The size of PLGA particles used to vaccinate mice can affect the magnitude of the …

Protein instability and immunogenicity are two main roadblocks to the clinical success of
novel protein drug delivery systems. In this commentary, we discuss the need for more …

Plants constitute a rich source of diverse classes of valuable phytochemicals (eg, phenolic
acids, flavonoids, carotenoids, alkaloids) with proven biological activity (eg, antioxidant, anti …

Balancing immunogenicity with inflammation is a central tenet of vaccine design, especially
for subunit vaccines that utilize traditional pro-inflammatory adjuvants. Here we report that by …

Pancreatic cancer (PC) is the fourth leading cause of cancer-related deaths in the US,
claiming approximately 43,000 lives every year. Much like other solid tumors, PC evades the …

Targeting pathogen recognition receptors on dendritic cells (DCs) offers the advantage of
triggering specific signaling pathways to induce a tailored and robust immune response. In …