Chronic pain patients often develop mental disorders, and anxiety disorders are common.
We hypothesize that the comorbid anxiety results from an imbalance between the reward …

Opioid use disorder (OUD) is a chronic brain disease which originates from long-term
neuroadaptations that develop after repeated opioid consumption and withdrawal episodes …

Prefrontal cortical (PFC) circuits provide top-down control of threat reactivity. This includes
ventromedial PFC (vmPFC) circuitry, which plays a role in suppressing fear-related …

Amygdaloid circuits are involved in a variety of emotional and motivation-related behaviors
and are impacted by stress. The amygdala expresses several neuromodulatory systems …

Several neurochemical systems converge in the prefrontal cortex (PFC) to regulate cognitive
and motivated behaviors. A rich network of endogenous opioid peptides and receptors …

Accumulating evidence from several studies has shown association between substance
use, dysregulation of the microbiome and psychiatric disorders such as depression, anxiety …

This paper is the forty-fourth consecutive installment of the annual anthological review of
research concerning the endogenous opioid system, summarizing articles published during …

Abstract The volatile compound 2, 4, 5-trimethylthiazoline (TMT, a synthetic predator scent)
triggers fear, anxiety, and defensive responses in rodents that can outlast the encounter. The …

The greater amberjack Seriola dumerili is a promising candidate for aquaculture production.
This study compares the ovary transcriptome of greater amberjack sampled in the wild …

Research into kappa opioid receptor (KOR) agonists with attenuated central-nervous-system
side effects is a critical focus for developing productive and safe analgesics. Herein, a series …