Despite tremendous successes in the field of antibiotic discovery seen in the previous
century, infectious diseases have remained a leading cause of death. More specifically …

The outer membranes of Gram-negative bacteria, mitochondria, and chloroplasts all contain
transmembrane β-barrel proteins. These β-barrel proteins serve essential functions in cargo …

Gram negative bacteria have evolved many mechanisms of attaching to and invading host
epithelial and immune cells. In particular, many outer membrane proteins (OMPs) are …

Presently, most simulations of ion channel function rely upon nonatomistic Brownian
dynamics calculations, indirect interpretation of energy maps, or application of external …

RA is a debilitating disorder that manifests as chronic localized synovial and systemic
inflammation leading to progressive joint destruction. Recent advances in the molecular …

Gram-negative bacteria are intrinsically resistant to many antibiotics, due in large part to the
permeability barrier formed by their cell envelope. The complex and synergistic interplay of …

Many Gram-negative bacteria, including human pathogens such as Pseudomonas
aeruginosa, do not have large-channel porins. This results in an outer membrane (OM) that …

Neisseria meningitidis is a leading bacterial cause of sepsis and meningitis globally with
dynamic strain distribution over time. Beginning with an epidemic among Hajj pilgrims in …

Ion channels are of universal importance for all cell types and play key roles in cellular
physiology and pathology. Increased insight into their functional mechanisms is crucial to …

Ligand-gated channels, in which a substrate transport pathway is formed as a result of the
binding of a small-molecule chemical messenger, constitute a diverse class of membrane …